Granzyme M (EC 3.4.21.-) (Met-1 serine protease) (Hu-Met-1) (Met-ase) (Natural killer cell granular protease)
1_MEACV 6_ SSLLV 11_ LALGA 16_ LSVGS 21_ SFGTQ 26_ IIGGR 31_ EVIPH 36_ SRPYM 41_ ASLQR 46_ NGSHL 51_ CGGVL 56_ VHPKW 61_ VLTAA 66_ HCLAQ 71_ RMAQL 76_ RLVLG 81_ LHTLD 86_ SPGLT 91_ FHIKA 96_ AIQHP 101_ RYKPV 106_ PALEN 111_ DLALL 116_ QLDGK 121_ VKPSR 126_ TIRPL 131_ ALPSK 136_ RQVVA 141_ AGTRC 146_ SMAGW 151_ GLTHQ 156_ GGRLS 161_ RVLRE 166_ LDLQV 171_ LDTRM 176_ CNNSR 181_ FWNGS 186_ LSPSM 191_ VCLAA 196_ DSKDQ 201_ APCKG 206_ DSGGP 211_ LVCGK 216_ GRVLA 221_ RVLSF 226_ SSRVC 231_ TDIFK 236_ PPVAT 241_ AVAPY 246_ VSWIR 251_KVTGR
1: Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells