Ras-related protein Rab-7a (EC 3.6.5.2)
1_MTSRK 6_ KVLLK 11_ VIILG 16_ DSGVG 21_ KTSLM 26_ NQYVN 31_ KKFSN 36_ QYKAT 41_ IGADF 46_ LTKEV 51_ MVDDR 56_ LVTMQ 61_ IWDTA 66_ GQERF 71_ QSLGV 76_ AFYRG 81_ ADCCV 86_ LVFDV 91_ TAPNT 96_ FKTLD 101_ SWRDE 106_ FLIQA 111_ SPRDP 116_ ENFPF 121_ VVLGN 126_ KIDLE 131_ NRQVA 136_ TKRAQ 141_ AWCYS 146_ KNNIP 151_ YFETS 156_ AKEAI 161_ NVEQA 166_ FQTIA 171_ RNALK 176_ QETEV 181_ ELYNE 186_ FPEPI 191_ KLDKN 196_ DRAKA 201_SAESC
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:38538795). In its active state, RAB7A binds to a variety of effector proteins playing a key role in the regulation of endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Also plays a central role in growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (PubMed:11179213, PubMed:12944476, PubMed:14617358, PubMed:20028791, PubMed:21255211). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Required for vesicular trafficking and cell surface expression of ACE2 (PubMed:33147445). May play a role in PRPH neuronal intermediate filament assembly (By similarity)