Ras-related protein Rab-9A
1_MAGKS 6_ SLFKV 11_ ILLGD 16_ GGVGK 21_ SSLMN 26_ RYVTN 31_ KFDTQ 36_ LFHTI 41_ GVEFL 46_ NKDLE 51_ VDGHF 56_ VTMQI 61_ WDTAG 66_ QERFR 71_ SLRTP 76_ FYRGS 81_ DCCLL 86_ TFSVD 91_ DSQSF 96_ QNLSN 101_ WKKEF 106_ IYYAD 111_ VKEPE 116_ SFPFV 121_ ILGNK 126_ IDISE 131_ RQVST 136_ EEAQA 141_ WCRDN 146_ GDYPY 151_ FETSA 156_ KDATN 161_ VAAAF 166_ EEAVR 171_ RVLAT 176_ EDRSD 181_ HLIQT 186_ DTVNL 191_ HRKPK 196_PSSSC
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB9A is involved in the transport of proteins between the endosomes and the trans-Golgi network (TGN) (PubMed:34793709). Specifically uses NDE1/NDEL1 as an effector to interact with the dynein motor complex in order to control retrograde trafficking of RAB9-associated late endosomes to the TGN (PubMed:34793709). Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity)