Ras-related protein Rab-13 (Cell growth-inhibiting gene 4 protein)
1_MAKAY 6_ DHLFK 11_ LLLIG 16_ DSGVG 21_ KTCLI 26_ IRFAE 31_ DNFNN 36_ TYIST 41_ IGIDF 46_ KIRTV 51_ DIEGK 56_ KIKLQ 61_ VWDTA 66_ GQERF 71_ KTITT 76_ AYYRG 81_ AMGII 86_ LVYDI 91_ TDEKS 96_ FENIQ 101_ NWMKS 106_ IKENA 111_ SAGVE 116_ RLLLG 121_ NKCDM 126_ EAKRK 131_ VQKEQ 136_ ADKLA 141_ REHGI 146_ RFFET 151_ SAKSS 156_ MNVDE 161_ AFSSL 166_ ARDIL 171_ LKSGG 176_ RRSGN 181_ GNKPP 186_ STDLK 191_ TCDKK 196_NTNKC
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB13 is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis