Ras-related protein Rab-28
1_MSDSE 6_ EESQD 11_ RQLKI 16_ VVLGD 21_ GASGK 26_ TSLTT 31_ CFAQE 36_ TFGKQ 41_ YKQTI 46_ GLDFF 51_ LRRIT 56_ LPGNL 61_ NVTLQ 66_ IWDIG 71_ GQTIG 76_ GKMLD 81_ KYIYG 86_ AQGVL 91_ LVYDI 96_ TNYQS 101_ FENLE 106_ DWYTV 111_ VKKVS 116_ EESET 121_ QPLVA 126_ LVGNK 131_ IDLEH 136_ MRTIK 141_ PEKHL 146_ RFCQE 151_ NGFSS 156_ HFVSA 161_ KTGDS 166_ VFLCF 171_ QKVAA 176_ EILGI 181_ KLNKA 186_ EIEQS 191_ QRVVK 196_ ADIVN 201_ YNQEP 206_ MSRTV 211_ NPPRS 216_SMCAV
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:8647132). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:8647132). RAB28 is required for shedding and phagocytosis of cone cell outer segments (OS) discs in the retina (By similarity). Also participates in nuclear factor kappa-B p65/RELA nuclear transport in endothelial cells (By similarity)