Ras-related protein Rab-27A (Rab-27) (EC 3.6.5.2) (GTP-binding protein Ram)
1_MSDGD 6_ YDYLI 11_ KFLAL 16_ GDSGV 21_ GKTSV 26_ LYQYT 31_ DGKFN 36_ SKFIT 41_ TVGID 46_ FREKR 51_ VVYRA 56_ SGPDG 61_ ATGRG 66_ QRIHL 71_ QLWDT 76_ AGQER 81_ FRSLT 86_ TAFFR 91_ DAMGF 96_ LLLFD 101_ LTNEQ 106_ SFLNV 111_ RNWIS 116_ QLQMH 121_ AYCEN 126_ PDIVL 131_ CGNKS 136_ DLEDQ 141_ RVVKE 146_ EEAIA 151_ LAEKY 156_ GIPYF 161_ ETSAA 166_ NGTNI 171_ SQAIE 176_ MLLDL 181_ IMKRM 186_ ERCVD 191_ KSWIP 196_ EGVVR 201_ SNGHA 206_ STDQL 211_ SEEKE 216_KGACG
1: Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (PubMed:30771381). Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse