Gastrotropin (GT) (Fatty acid-binding protein 6) (Ileal lipid-binding protein) (ILBP) (Intestinal 15 kDa protein) (I-15P) (Intestinal bile acid-binding protein) (I-BABP)
1_MAFTG 6_ KFEME 11_ SEKNY 16_ DEFMK 21_ LLGIS 26_ SDVIE 31_ KARNF 36_ KIVTE 41_ VQQDG 46_ QDFTW 51_ SQHYS 56_ GGHTM 61_ TNKFT 66_ VGKES 71_ NIQTM 76_ GGKTF 81_ KATVQ 86_ MEGGK 91_ LVVNF 96_ PNYHQ 101_ TSEIV 106_ GDKLV 111_ EVSTI 116_ GGVTY 121_ERVSK
1: Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By similarity). In vitro binds to bile acids in the order: deoxycholic acid > cholic acid > chenodeoxycholic acid and respective BA conjugation modifies affinities in the order taurine-conjugated > glycine-conjugated > unconjugated bile acids. Stimulates gastric acid and pepsinogen secretion (By similarity)
2: Essential for the survival of colon cancer cells to bile acid-induced apoptosis