Amiloride-sensitive sodium channel subunit beta (Beta-NaCH) (Epithelial Na(+) channel subunit beta) (Beta-ENaC) (ENaCB) (Nonvoltage-gated sodium channel 1 subunit beta) (SCNEB)
1_MHVKK 6_ YLLKG 11_ LHRLQ 16_ KGPGY 21_ TYKEL 26_ LVWYC 31_ DNTNT 36_ HGPKR 41_ IICEG 46_ PKKKA 51_ MWFLL 56_ TLLFA 61_ ALVCW 66_ QWGIF 71_ IRTYL 76_ SWEVS 81_ VSLSV 86_ GFKTM 91_ DFPAV 96_ TICNA 101_ SPFKY 106_ SKIKH 111_ LLKDL 116_ DELME 121_ AVLER 126_ ILAPE 131_ LSHAN 136_ ATRNL 141_ NFSIW 146_ NHTPL 151_ VLIDE 156_ RNPHH 161_ PMVLD 166_ LFGDN 171_ HNGLT 176_ SSSAS 181_ EKICN 186_ AHGCK 191_ MAMRL 196_ CSLNR 201_ TQCTF 206_ RNFTS 211_ ATQAL 216_ TEWYI 221_ LQATN 226_ IFAQV 231_ PQQEL 236_ VEMSY 241_ PGEQM 246_ ILACL 251_ FGAEP 256_ CNYRN 261_ FTSIF 266_ YPHYG 271_ NCYIF 276_ NWGMT 281_ EKALP 286_ SANPG 291_ TEFGL 296_ KLILD 301_ IGQED 306_ YVPFL 311_ ASTAG 316_ VRLML 321_ HEQRS 326_ YPFIR 331_ DEGIY 336_ AMSGT 341_ ETSIG 346_ VLVDK 351_ LQRMG 356_ EPYSP 361_ CTVNG 366_ SEVPV 371_ QNFYS 376_ DYNTT 381_ YSIQA 386_ CLRSC 391_ FQDHM 396_ IRNCN 401_ CGHYL 406_ YPLPR 411_ GEKYC 416_ NNRDF 421_ PDWAH 426_ CYSDL 431_ QMSVA 436_ QRETC 441_ IGMCK 446_ ESCND 451_ TQYKM 456_ TISMA 461_ DWPSE 466_ ASEDW 471_ IFHVL 476_ SQERD 481_ QSTNI 486_ TLSRK 491_ GIVKL 496_ NIYFQ 501_ EFNYR 506_ TIEES 511_ AANNI 516_ VWLLS 521_ NLGGQ 526_ FGFWM 531_ GGSVL 536_ CLIEF 541_ GEIII 546_ DFVWI 551_ TIIKL 556_ VALAK 561_ SLRQR 566_ RAQAS 571_ YAGPP 576_ PTVAE 581_ LVEAH 586_ TNFGF 591_ QPDTA 596_ PRSPN 601_ TGPYP 606_ SEQAL 611_ PIPGT 616_ PPPNY 621_ DSLRL 626_ QPLDV 631_IESDS
1: This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis (PubMed:30251954, PubMed:32729833, PubMed:7762608, PubMed:9792722). ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically (PubMed:24124190). It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys (PubMed:12107247). Additionally, ENaC is essential for airway surface liquid homeostasis, which is crucial for proper mucus clearance (PubMed:24124190)