Amiloride-sensitive sodium channel subunit gamma (Epithelial Na(+) channel subunit gamma) (ENaCG) (Gamma-ENaC) (Gamma-NaCH) (Nonvoltage-gated sodium channel 1 subunit gamma) (SCNEG)
1_MAPGE 6_ KIKAK 11_ IKKNL 16_ PVTGP 21_ QAPTI 26_ KELMR 31_ WYCLN 36_ TNTHG 41_ CRRIV 46_ VSRGR 51_ LRRLL 56_ WIGFT 61_ LTAVA 66_ LILWQ 71_ CALLV 76_ FSFYT 81_ VSVSI 86_ KVHFR 91_ KLDFP 96_ AVTIC 101_ NINPY 106_ KYSTV 111_ RHLLA 116_ DLEQE 121_ TREAL 126_ KSLYG 131_ FPESR 136_ KRREA 141_ ESWNS 146_ VSEGK 151_ QPRFS 156_ HRIPL 161_ LIFDQ 166_ DEKGK 171_ ARDFF 176_ TGRKR 181_ KVGGS 186_ IIHKA 191_ SNVMH 196_ IESKQ 201_ VVGFQ 206_ LCSND 211_ TSDCA 216_ TYTFS 221_ SGINA 226_ IQEWY 231_ KLHYM 236_ NIMAQ 241_ VPLEK 246_ KINMS 251_ YSAEE 256_ LLVTC 261_ FFDGV 266_ SCDAR 271_ NFTLF 276_ HHPMH 281_ GNCYT 286_ FNNRE 291_ NETIL 296_ STSMG 301_ GSEYG 306_ LQVIL 311_ YINEE 316_ EYNPF 321_ LVSST 326_ GAKVI 331_ IHRQD 336_ EYPFV 341_ EDVGT 346_ EIETA 351_ MVTSI 356_ GMHLT 361_ ESFKL 366_ SEPYS 371_ QCTED 376_ GSDVP 381_ IRNIY 386_ NAAYS 391_ LQICL 396_ HSCFQ 401_ TKMVE 406_ KCGCA 411_ QYSQP 416_ LPPAA 421_ NYCNY 426_ QQHPN 431_ WMYCY 436_ YQLHR 441_ AFVQE 446_ ELGCQ 451_ SVCKE 456_ ACSFK 461_ EWTLT 466_ TSLAQ 471_ WPSVV 476_ SEKWL 481_ LPVLT 486_ WDQGR 491_ QVNKK 496_ LNKTD 501_ LAKLL 506_ IFYKD 511_ LNQRS 516_ IMESP 521_ ANSIE 526_ MLLSN 531_ FGGQL 536_ GLWMS 541_ CSVVC 546_ VIEII 551_ EVFFI 556_ DFFSI 561_ IARRQ 566_ WQKAK 571_ EWWAW 576_ KQAPP 581_ CPEAP 586_ RSPQG 591_ QDNPA 596_ LDIDD 601_ DLPTF 606_ NSALH 611_ LPPAL 616_ GTQVP 621_ GTPPP 626_ KYNTL 631_ RLERA 636_ FSNQL 641_TDTQM
1: This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis (PubMed:30251954, PubMed:32729833, PubMed:7550319, PubMed:7762608, PubMed:9792722). ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically (PubMed:24124190). It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys (PubMed:12107247, PubMed:7550319, PubMed:8640238). Additionally, ENaC is essential for airway surface liquid homeostasis, which is crucial for proper mucus clearance (PubMed:18507830, PubMed:19017867, PubMed:24124190)