Amiloride-sensitive sodium channel subunit delta (Delta-NaCH) (Epithelial Na(+) channel subunit delta) (Delta-ENaC) (ENaCD) (Nonvoltage-gated sodium channel 1 subunit delta) (SCNED)
1_MRAVL 6_ SQKTT 11_ PLPRY 16_ LWPGH 21_ LSGPR 26_ RLTWS 31_ WCSDH 36_ RTPTC 41_ RELGS 46_ PHPTP 51_ CTGPA 56_ RGWPR 61_ RGGGP 66_ CGFTS 71_ AGHVL 76_ CGYPL 81_ CLLSG 86_ PIQGC 91_ GTGLG 96_ DSSMA 101_ FLSRT 106_ SPVAA 111_ ASFQS 116_ RQEAR 121_ GSILL 126_ QSCQL 131_ PPQWL 136_ STEAW 141_ TGEWK 146_ QPHGG 151_ ALTSR 156_ SPGPV 161_ APQRP 166_ CHLKG 171_ WQHRP 176_ TQHNA 181_ ACKQG 186_ QAAAQ 191_ TPPRP 196_ GPPSA 201_ PPPPP 206_ KEGHQ 211_ EGLVE 216_ LPASF 221_ RELLT 226_ FFCTN 231_ ATIHG 236_ AIRLV 241_ CSRGN 246_ RLKTT 251_ SWGLL 256_ SLGAL 261_ VALCW 266_ QLGLL 271_ FERHW 276_ HRPVL 281_ MAVSV 286_ HSERK 291_ LLPLV 296_ TLCDG 301_ NPRRP 306_ SPVLR 311_ HLELL 316_ DEFAR 321_ ENIDS 326_ LYNVN 331_ LSKGR 336_ AALSA 341_ TVPRH 346_ EPPFH 351_ LDREI 356_ RLQRL 361_ SHSGS 366_ RVRVG 371_ FRLCN 376_ STGGD 381_ CFYRG 386_ YTSGV 391_ AAVQD 396_ WYHFH 401_ YVDIL 406_ ALLPA 411_ AWEDS 416_ HGSQD 421_ GHFVL 426_ SCSYD 431_ GLDCQ 436_ ARQFR 441_ TFHHP 446_ TYGSC 451_ YTVDG 456_ VWTAQ 461_ RPGIT 466_ HGVGL 471_ VLRVE 476_ QQPHL 481_ PLLST 486_ LAGIR 491_ VMVHG 496_ RNHTP 501_ FLGHH 506_ SFSVR 511_ PGTEA 516_ TISIR 521_ EDEVH 526_ RLGSP 531_ YGHCT 536_ AGGEG 541_ VEVEL 546_ LHNTS 551_ YTRQA 556_ CLVSC 561_ FQQLM 566_ VETCS 571_ CGYYL 576_ HPLPA 581_ GAEYC 586_ SSARH 591_ PAWGH 596_ CFYRL 601_ YQDLE 606_ THRLP 611_ CTSRC 616_ PRPCR 621_ ESAFK 626_ LSTGT 631_ SRWPS 636_ AKSAG 641_ WTLAT 646_ LGEQG 651_ LPHQS 656_ HRQRS 661_ SLAKI 666_ NIVYQ 671_ ELNYR 676_ SVEEA 681_ PVYSV 686_ PQLLS 691_ AMGSL 696_ CSLWF 701_ GASVL 706_ SLLEL 711_ LELLL 716_ DASAL 721_ TLVLG 726_ GRRLR 731_ RAWFS 736_ WPRAS 741_ PASGA 746_ SSIKP 751_ EASQM 756_ PPPAG 761_ GTSDD 766_ PEPSG 771_ PHLPR 776_ VMLPG 781_ VLAGV 786_ SAEES 791_ WAGPQ 796_PLETL
1: Potential alternative pore-forming subunit of the epithelial sodium channel (ENaC), capable of replacing the alpha/SCNN1A subunit, creating a more active channel with distinct properties (PubMed:16423824, PubMed:19520916, PubMed:22505667). ENaC functions in epithelial tissues, where it facilitates the electrodiffusion of sodium ions from the extracellular fluid through the apical membrane of cells, with water following osmotically, regulating sodium balance and fluid homeostasis (PubMed:16423824, PubMed:19520916, PubMed:7499195). This subunit could also function independently as a sodium channel or assemble into other tissue-specific heterotrimeric sodium channels (PubMed:7499195)
2: ENaC channels including this isoform exhibit greater conductance