Death-associated protein 1 (DAP-1)
1_MSSPP 6_ EGKLE 11_ TKAGH 16_ PPAVK 21_ AGGMR 26_ IVQKH 31_ PHTGD 36_ TKEEK 41_ DKDDQ 46_ EWESP 51_ SPPKP 56_ TVFIS 61_ GVIAR 66_ GDKDF 71_ PPAAA 76_ QVAHQ 81_ KPHAS 86_ MDKHP 91_ SPRTQ 96_HIQQP
1: Ribosome-binding protein involved in ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (By similarity). Acts via its association with eiF5a (EIF5A and EIF5A2) at the polypeptide exit tunnel of the ribosome, preventing mRNA translation (By similarity). Involved in ribosome hibernation in the mature oocyte by preventing mRNA translation, leading to ribosome inactivation (By similarity). Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the oocyte and early embryo (By similarity). Also acts as a negative regulator of autophagy (PubMed:20537536). Involved in mediating interferon-gamma-induced cell death (PubMed:7828849)