Tyrosine-protein kinase Blk (EC 2.7.10.2) (B lymphocyte kinase) (p55-Blk)
1_MGLVS 6_ SKKPD 11_ KEKPI 16_ KEKDK 21_ GQWSP 26_ LKVSA 31_ QDKDA 36_ PPLPP 41_ LVVFN 46_ HLTPP 51_ PPDEH 56_ LDEDK 61_ HFVVA 66_ LYDYT 71_ AMNDR 76_ DLQML 81_ KGEKL 86_ QVLKG 91_ TGDWW 96_ LARSL 101_ VTGRE 106_ GYVPS 111_ NFVAR 116_ VESLE 121_ MERWF 126_ FRSQG 131_ RKEAE 136_ RQLLA 141_ PINKA 146_ GSFLI 151_ RESET 156_ NKGAF 161_ SLSVK 166_ DVTTQ 171_ GELIK 176_ HYKIR 181_ CLDEG 186_ GYYIS 191_ PRITF 196_ PSLQA 201_ LVQHY 206_ SKKGD 211_ GLCQR 216_ LTLPC 221_ VRPAP 226_ QNPWA 231_ QDEWE 236_ IPRQS 241_ LRLVR 246_ KLGSG 251_ QFGEV 256_ WMGYY 261_ KNNMK 266_ VAIKT 271_ LKEGT 276_ MSPEA 281_ FLGEA 286_ NVMKA 291_ LQHER 296_ LVRLY 301_ AVVTK 306_ EPIYI 311_ VTEYM 316_ ARGCL 321_ LDFLK 326_ TDEGS 331_ RLSLP 336_ RLIDM 341_ SAQIA 346_ EGMAY 351_ IERMN 356_ SIHRD 361_ LRAAN 366_ ILVSE 371_ ALCCK 376_ IADFG 381_ LARII 386_ DSEYT 391_ AQEGA 396_ KFPIK 401_ WTAPE 406_ AIHFG 411_ VFTIK 416_ ADVWS 421_ FGVLL 426_ MEVVT 431_ YGRVP 436_ YPGMS 441_ NPEVI 446_ RNLER 451_ GYRMP 456_ RPDTC 461_ PPELY 466_ RGVIA 471_ ECWRS 476_ RPEER 481_ PTFEF 486_ LQSVL 491_ EDFYT 496_ATERQ
1: Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling (By similarity). B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors (By similarity). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (By similarity). Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor (By similarity). Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207' (By similarity). Also phosphorylates the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C (PubMed:8756631). With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation (By similarity). Also contributes to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation (By similarity). In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose (PubMed:19667185). Phosphorylates CGAS, promoting retention of CGAS in the cytosol (PubMed:30356214)