Matrix metalloproteinase-16 (MMP-16) (EC 3.4.24.-) (MMP-X2) (Membrane-type matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3) (Membrane-type-3 matrix metalloproteinase) (MT3-MMP) (MT3MMP)
1_MILLT 6_ FSTGR 11_ RLDFV 16_ HHSGV 21_ FFLQT 26_ LLWIL 31_ CATVC 36_ GTEQY 41_ FNVEV 46_ WLQKY 51_ GYLPP 56_ TDPRM 61_ SVLRS 66_ AETMQ 71_ SALAA 76_ MQQFY 81_ GINMT 86_ GKVDR 91_ NTIDW 96_ MKKPR 101_ CGVPD 106_ QTRGS 111_ SKFHI 116_ RRKRY 121_ ALTGQ 126_ KWQHK 131_ HITYS 136_ IKNVT 141_ PKVGD 146_ PETRK 151_ AIRRA 156_ FDVWQ 161_ NVTPL 166_ TFEEV 171_ PYSEL 176_ ENGKR 181_ DVDIT 186_ IIFAS 191_ GFHGD 196_ SSPFD 201_ GEGGF 206_ LAHAY 211_ FPGPG 216_ IGGDT 221_ HFDSD 226_ EPWTL 231_ GNPNH 236_ DGNDL 241_ FLVAV 246_ HELGH 251_ ALGLE 256_ HSNDP 261_ TAIMA 266_ PFYQY 271_ METDN 276_ FKLPN 281_ DDLQG 286_ IQKIY 291_ GPPDK 296_ IPPPT 301_ RPLPT 306_ VPPHR 311_ SIPPA 316_ DPRKN 321_ DRPKP 326_ PRPPT 331_ GRPSY 336_ PGAKP 341_ NICDG 346_ NFNTL 351_ AILRR 356_ EMFVF 361_ KDQWF 366_ WRVRN 371_ NRVMD 376_ GYPMQ 381_ ITYFW 386_ RGLPP 391_ SIDAV 396_ YENSD 401_ GNFVF 406_ FKGNK 411_ YWVFK 416_ DTTLQ 421_ PGYPH 426_ DLITL 431_ GSGIP 436_ PHGID 441_ SAIWW 446_ EDVGK 451_ TYFFK 456_ GDRYW 461_ RYSEE 466_ MKTMD 471_ PGYPK 476_ PITVW 481_ KGIPE 486_ SPQGA 491_ FVHKE 496_ NGFTY 501_ FYKGK 506_ EYWKF 511_ NNQIL 516_ KVEPG 521_ YPRSI 526_ LKDFM 531_ GCDGP 536_ TDRVK 541_ EGHSP 546_ PDDVD 551_ IVIKL 556_ DNTAS 561_ TVKAI 566_ AIVIP 571_ CILAL 576_ CLLVL 581_ VYTVF 586_ QFKRK 591_ GTPRH 596_ ILYCK 601_RSMQE
1: Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells