DNA replication ATP-dependent helicase/nuclease DNA2 (hDNA2) (DNA replication ATP-dependent helicase-like homolog) [Includes: DNA replication nuclease DNA2 (EC 3.1.-.-); DNA replication ATP-dependent helicase DNA2 (EC 3.6.4.12)]
1_MEQLN 6_ ELELL 11_ MEKSF 16_ WEEAE 21_ LPAEL 26_ FQKKV 31_ VASFP 36_ RTVLS 41_ TGMDN 46_ RYLVL 51_ AVNTV 56_ QNKEG 61_ NCEKR 66_ LVITA 71_ SQSLE 76_ NKELC 81_ ILRND 86_ WCSVP 91_ VEPGD 96_ IIHLE 101_ GDCTS 106_ DTWII 111_ DKDFG 116_ YLILY 121_ PDMLI 126_ SGTSI 131_ ASSIR 136_ CMRRA 141_ VLSET 146_ FRSSD 151_ PATRQ 156_ MLIGT 161_ VLHEV 166_ FQKAI 171_ NNSFA 176_ PEKLQ 181_ ELAFQ 186_ TIQEI 191_ RHLKE 196_ MYRLN 201_ LSQDE 206_ IKQEV 211_ EDYLP 216_ SFCKW 221_ AGDFM 226_ HKNTS 231_ TDFPQ 236_ MQLSL 241_ PSDNS 246_ KDNST 251_ CNIEV 256_ VKPMD 261_ IEESI 266_ WSPRF 271_ GLKGK 276_ IDVTV 281_ GVKIH 286_ RGYKT 291_ KYKIM 296_ PLELK 301_ TGKES 306_ NSIEH 311_ RSQVV 316_ LYTLL 321_ SQERR 326_ ADPEA 331_ GLLLY 336_ LKTGQ 341_ MYPVP 346_ ANHLD 351_ KRELL 356_ KLRNQ 361_ MAFSL 366_ FHRIS 371_ KSATR 376_ QKTQL 381_ ASLPQ 386_ IIEEE 391_ KTCKY 396_ CSQIG 401_ NCALY 406_ SRAVE 411_ QQMDC 416_ SSVPI 421_ VMLPK 426_ IEEET 431_ QHLKQ 436_ THLEY 441_ FSLWC 446_ LMLTL 451_ ESQSK 456_ DNKKN 461_ HQNIW 466_ LMPAS 471_ EMEKS 476_ GSCIG 481_ NLIRM 486_ EHVKI 491_ VCDGQ 496_ YLHNF 501_ QCKHG 506_ AIPVT 511_ NLMAG 516_ DRVIV 521_ SGEER 526_ SLFAL 531_ SRGYV 536_ KEINM 541_ TTVTC 546_ LLDRN 551_ LSVLP 556_ ESTLF 561_ RLDQE 566_ EKNCD 571_ IDTPL 576_ GNLSK 581_ LMENT 586_ FVSKK 591_ LRDLI 596_ IDFRE 601_ PQFIS 606_ YLSSV 611_ LPHDA 616_ KDTVA 621_ CILKG 626_ LNKPQ 631_ RQAMK 636_ KVLLS 641_ KDYTL 646_ IVGMP 651_ GTGKT 656_ TTICT 661_ LVRIL 666_ YACGF 671_ SVLLT 676_ SYTHS 681_ AVDNI 686_ LLKLA 691_ KFKIG 696_ FLRLG 701_ QIQKV 706_ HPAIQ 711_ QFTEQ 716_ EICRS 721_ KSIKS 726_ LALLE 731_ ELYNS 736_ QLIVA 741_ TTCMG 746_ INHPI 751_ FSRKI 756_ FDFCI 761_ VDEAS 766_ QISQP 771_ ICLGP 776_ LFFSR 781_ RFVLV 786_ GDHQQ 791_ LPPLV 796_ LNREA 801_ RALGM 806_ SESLF 811_ KRLEQ 816_ NKSAV 821_ VQLTV 826_ QYRMN 831_ SKIMS 836_ LSNKL 841_ TYEGK 846_ LECGS 851_ DKVAN 856_ AVINL 861_ RHFKD 866_ VKLEL 871_ EFYAD 876_ YSDNP 881_ WLMGV 886_ FEPNN 891_ PVCFL 896_ NTDKV 901_ PAPEQ 906_ VEKGG 911_ VSNVT 916_ EAKLI 921_ VFLTS 926_ IFVKA 931_ GCSPS 936_ DIGII 941_ APYRQ 946_ QLKII 951_ NDLLA 956_ RSIGM 961_ VEVNT 966_ VDKYQ 971_ GRDKS 976_ IVLVS 981_ FVRSN 986_ KDGTV 991_ GELLK 996_ DWRRL 1001_ NVAIT 1006_ RAKHK 1011_ LILLG 1016_ CVPSL 1021_ NCYPP 1026_ LEKLL 1031_ NHLNS 1036_ EKLII 1041_ DLPSR 1046_ EHESL 1051_CHILG
1: Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate. According to various reports, the helicase activity is weak and its function remains largely unclear. Helicase activity may promote the motion of DNA2 on the flap, helping the nuclease function