Transcription activator BRG1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA4) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4)
1_MSTPD 6_ PPLGG 11_ TPRPG 16_ PSPGP 21_ GPSPG 26_ AMLGP 31_ SPGPS 36_ PGSAH 41_ SMMGP 46_ SPGPP 51_ SAGHP 56_ IPTQG 61_ PGGYP 66_ QDNMH 71_ QMHKP 76_ MESMH 81_ EKGMS 86_ DDPRY 91_ NQMKG 96_ MGMRS 101_ GGHAG 106_ MGPPP 111_ SPMDQ 116_ HSQGY 121_ PSPLG 126_ GSEHA 131_ SSPVP 136_ ASGPS 141_ SGPQM 146_ SSGPG 151_ GAPLD 156_ GADPQ 161_ ALGQQ 166_ NRGPT 171_ PFNQN 176_ QLHQL 181_ RAQIM 186_ AYKML 191_ ARGQP 196_ LPDHL 201_ QMAVQ 206_ GKRPM 211_ PGMQQ 216_ QMPTL 221_ PPPSV 226_ SATGP 231_ GPGPG 236_ PGPGP 241_ GPGPA 246_ PPNYS 251_ RPHGM 256_ GGPNM 261_ PPPGP 266_ SGVPP 271_ GMPGQ 276_ PPGGP 281_ PKPWP 286_ EGPMA 291_ NAAAP 296_ TSTPQ 301_ KLIPP 306_ QPTGR 311_ PSPAP 316_ PAVPP 321_ AASPV 326_ MPPQT 331_ QSPGQ 336_ PAQPA 341_ PMVPL 346_ HQKQS 351_ RITPI 356_ QKPRG 361_ LDPVE 366_ ILQER 371_ EYRLQ 376_ ARIAH 381_ RIQEL 386_ ENLPG 391_ SLAGD 396_ LRTKA 401_ TIELK 406_ ALRLL 411_ NFQRQ 416_ LRQEV 421_ VVCMR 426_ RDTAL 431_ ETALN 436_ AKAYK 441_ RSKRQ 446_ SLREA 451_ RITEK 456_ LEKQQ 461_ KIEQE 466_ RKRRQ 471_ KHQEY 476_ LNSIL 481_ QHAKD 486_ FKEYH 491_ RSVTG 496_ KIQKL 501_ TKAVA 506_ TYHAN 511_ TEREQ 516_ KKENE 521_ RIEKE 526_ RMRRL 531_ MAEDE 536_ EGYRK 541_ LIDQK 546_ KDKRL 551_ AYLLQ 556_ QTDEY 561_ VANLT 566_ ELVRQ 571_ HKAAQ 576_ VAKEK 581_ KKKKK 586_ KKKAE 591_ NAEGQ 596_ TPAIG 601_ PDGEP 606_ LDETS 611_ QMSDL 616_ PVKVI 621_ HVESG 626_ KILTG 631_ TDAPK 636_ AGQLE 641_ AWLEM 646_ NPGYE 651_ VAPRS 656_ DSEES 661_ GSEEE 666_ EEEEE 671_ EEQPQ 676_ AAQPP 681_ TLPVE 686_ EKKKI 691_ PDPDS 696_ DDVSE 701_ VDARH 706_ IIENA 711_ KQDVD 716_ DEYGV 721_ SQALA 726_ RGLQS 731_ YYAVA 736_ HAVTE 741_ RVDKQ 746_ SALMV 751_ NGVLK 756_ QYQIK 761_ GLEWL 766_ VSLYN 771_ NNLNG 776_ ILADE 781_ MGLGK 786_ TIQTI 791_ ALITY 796_ LMEHK 801_ RINGP 806_ FLIIV 811_ PLSTL 816_ SNWAY 821_ EFDKW 826_ APSVV 831_ KVSYK 836_ GSPAA 841_ RRAFV 846_ PQLRS 851_ GKFNV 856_ LLTTY 861_ EYIIK 866_ DKHIL 871_ AKIRW 876_ KYMIV 881_ DEGHR 886_ MKNHH 891_ CKLTQ 896_ VLNTH 901_ YVAPR 906_ RLLLT 911_ GTPLQ 916_ NKLPE 921_ LWALL 926_ NFLLP 931_ TIFKS 936_ CSTFE 941_ QWFNA 946_ PFAMT 951_ GEKVD 956_ LNEEE 961_ TILII 966_ RRLHK 971_ VLRPF 976_ LLRRL 981_ KKEVE 986_ AQLPE 991_ KVEYV 996_ IKCDM 1001_ SALQR 1006_ VLYRH 1011_ MQAKG 1016_ VLLTD 1021_ GSEKD 1026_ KKGKG 1031_ GTKTL 1036_ MNTIM 1041_ QLRKI 1046_ CNHPY 1051_ MFQHI 1056_ EESFS 1061_ EHLGF 1066_ TGGIV 1071_ QGLDL 1076_ YRASG 1081_ KFELL 1086_ DRILP 1091_ KLRAT 1096_ NHKVL 1101_ LFCQM 1106_ TSLMT 1111_ IMEDY 1116_ FAYRG 1121_ FKYLR 1126_ LDGTT 1131_ KAEDR 1136_ GMLLK 1141_ TFNEP 1146_ GSEYF 1151_ IFLLS 1156_ TRAGG 1161_ LGLNL 1166_ QSADT 1171_ VIIFD 1176_ SDWNP 1181_ HQDLQ 1186_ AQDRA 1191_ HRIGQ 1196_ QNEVR 1201_ VLRLC 1206_ TVNSV 1211_ EEKIL 1216_ AAAKY 1221_ KLNVD 1226_ QKVIQ 1231_ AGMFD 1236_ QKSSS 1241_ HERRA 1246_ FLQAI 1251_ LEHEE 1256_ QDESR 1261_ HCSTG 1266_ SGSAS 1271_ FAHTA 1276_ PPPAG 1281_ VNPDL 1286_ EEPPL 1291_ KEEDE 1296_ VPDDE 1301_ TVNQM 1306_ IARHE 1311_ EEFDL 1316_ FMRMD 1321_ LDRRR 1326_ EEARN 1331_ PKRKP 1336_ RLMEE 1341_ DELPS 1346_ WIIKD 1351_ DAEVE 1356_ RLTCE 1361_ EEEEK 1366_ MFGRG 1371_ SRHRK 1376_ EVDYS 1381_ DSLTE 1386_ KQWLK 1391_ AIEEG 1396_ TLEEI 1401_ EEEVR 1406_ QKKSS 1411_ RKRKR 1416_ DSDAG 1421_ SSTPT 1426_ TSTRS 1431_ RDKDD 1436_ ESKKQ 1441_ KKRGR 1446_ PPAEK 1451_ LSPNP 1456_ PNLTK 1461_ KMKKI 1466_ VDAVI 1471_ KYKDS 1476_ SSGRQ 1481_ LSEVF 1486_ IQLPS 1491_ RKELP 1496_ EYYEL 1501_ IRKPV 1506_ DFKKI 1511_ KERIR 1516_ NHKYR 1521_ SLNDL 1526_ EKDVM 1531_ LLCQN 1536_ AQTFN 1541_ LEGSL 1546_ IYEDS 1551_ IVLQS 1556_ VFTSV 1561_ RQKIE 1566_ KEDDS 1571_ EGEES 1576_ EEEEE 1581_ GEEEG 1586_ SESES 1591_ RSVKV 1596_ KIKLG 1601_ RKEKA 1606_ QDRLK 1611_ GGRRR 1616_ PSRGS 1621_ RAKPV 1626_ VSDDD 1631_ SEEEQ 1636_ EEDRS 1641_GSGSE
1: ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:15075294, PubMed:29374058, PubMed:30339381, PubMed:32459350). Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1 (PubMed:20418909). Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). Binds to RNA in a promiscuous manner (By similarity). In brown adipose tissue, involved in the regulation of thermogenic genes expression (By similarity)