Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (Isocitric dehydrogenase subunit gamma) (NAD(+)-specific ICDH subunit gamma)
1_MALKV 6_ ATVAG 11_ SAAKA 16_ VLGPA 21_ LLCRP 26_ WEVLG 31_ AHEVP 36_ SRNIF 41_ SEQTI 46_ PPSAK 51_ YGGRH 56_ TVTMI 61_ PGDGI 66_ GPELM 71_ LHVKS 76_ VFRHA 81_ CVPVD 86_ FEEVH 91_ VSSNA 96_ DEEDI 101_ RNAIM 106_ AIRRN 111_ RVALK 116_ GNIET 121_ NHNLP 126_ PSHKS 131_ RNNIL 136_ RTSLD 141_ LYANV 146_ IHCKS 151_ LPGVV 156_ TRHKD 161_ IDILI 166_ VRENT 171_ EGEYS 176_ SLEHE 181_ SVAGV 186_ VESLK 191_ IITKA 196_ KSLRI 201_ AEYAF 206_ KLAQE 211_ SGRKK 216_ VTAVH 221_ KANIM 226_ KLGDG 231_ LFLQC 236_ CREVA 241_ ARYPQ 246_ ITFEN 251_ MIVDN 256_ TTMQL 261_ VSRPQ 266_ QFDVM 271_ VMPNL 276_ YGNIV 281_ NNVCA 286_ GLVGG 291_ PGLVA 296_ GANYG 301_ HVYAV 306_ FETAT 311_ RNTGK 316_ SIANK 321_ NIANP 326_ TATLL 331_ ASCMM 336_ LDHLK 341_ LHSYA 346_ TSIRK 351_ AVLAS 356_ MDNEN 361_ MHTPD 366_ IGGQG 371_ TTSEA 376_ IQDVI 381_ RHIRV 386_INGRA
1: Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers