B-cell receptor-associated protein 31 (BCR-associated protein 31) (Bap31) (6C6-AG tumor-associated antigen) (Protein CDM) (p28)
1_MSLQW 6_ TAVAT 11_ FLYAE 16_ VFVVL 21_ LLCIP 26_ FISPK 31_ RWQKI 36_ FKSRL 41_ VELLV 46_ SYGNT 51_ FFVVL 56_ IVILV 61_ LLVID 66_ AVREI 71_ RKYDD 76_ VTEKV 81_ NLQNN 86_ PGAME 91_ HFHMK 96_ LFRAQ 101_ RNLYI 106_ AGFSL 111_ LLSFL 116_ LRRLV 121_ TLISQ 126_ QATLL 131_ ASNEA 136_ FKKQA 141_ ESASE 146_ AAKKY 151_ MEEND 156_ QLKKG 161_ AAVDG 166_ GKLDV 171_ GNAEV 176_ KLEEE 181_ NRSLK 186_ ADLQK 191_ LKDEL 196_ ASTKQ 201_ KLEKA 206_ ENQVL 211_ AMRKQ 216_ SEGLT 221_ KEYDR 226_ LLEEH 231_ AKLQA 236_ AVDGP 241_MDKKE
1: Functions as a chaperone protein (PubMed:18287538, PubMed:9396746). Is one of the most abundant endoplasmic reticulum (ER) proteins (PubMed:18287538, PubMed:9396746). Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD) (PubMed:18287538, PubMed:9396746). Also serves as a cargo receptor for the export of transmembrane proteins (By similarity). Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by stimulating the translocation of NDUFS4 and NDUFB11 from the cytosol to the mitochondria via interaction with TOMM40 (PubMed:31206022). In response to ER stress, delocalizes from the ER-mitochondria contact sites and binds BCL2 (PubMed:31206022). May be involved in CASP8-mediated apoptosis (PubMed:10958671)