P2X purinoceptor 1 (P2X1) (ATP receptor) (Purinergic receptor)
1_MARRF 6_ QEELA 11_ AFLFE 16_ YDTPR 21_ MVLVR 26_ NKKVG 31_ VIFRL 36_ IQLVV 41_ LVYVI 46_ GWVFL 51_ YEKGY 56_ QTSSG 61_ LISSV 66_ SVKLK 71_ GLAVT 76_ QLPGL 81_ GPQVW 86_ DVADY 91_ VFPAQ 96_ GDNSF 101_ VVMTN 106_ FIVTP 111_ KQTQG 116_ YCAEH 121_ PEGGI 126_ CKEDS 131_ GCTPG 136_ KAKRK 141_ AQGIR 146_ TGKCV 151_ AFNDT 156_ VKTCE 161_ IFGWC 166_ PVEVD 171_ DDIPR 176_ PALLR 181_ EAENF 186_ TLFIK 191_ NSISF 196_ PRFKV 201_ NRRNL 206_ VEEVN 211_ AAHMK 216_ TCLFH 221_ KTLHP 226_ LCPVF 231_ QLGYV 236_ VQESG 241_ QNFST 246_ LAEKG 251_ GVVGI 256_ TIDWH 261_ CDLDW 266_ HVRHC 271_ RPIYE 276_ FHGLY 281_ EEKNL 286_ SPGFN 291_ FRFAR 296_ HFVEN 301_ GTNYR 306_ HLFKV 311_ FGIRF 316_ DILVD 321_ GKAGK 326_ FDIIP 331_ TMTTI 336_ GSGIG 341_ IFGVA 346_ TVLCD 351_ LLLLH 356_ ILPKR 361_ HYYKQ 366_ KKFKY 371_ AEDMG 376_ PGAAE 381_ RDLAA 386_ TSSTL 391_GLQEN
1: ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and with relatively high calcium permeability (PubMed:10440098, PubMed:15056721, PubMed:20699225, PubMed:8834001, PubMed:8961184). Furthermore, CTP functions as a weak affinity agonist for P2RX1 (PubMed:14699168). Plays a role a role in urogenital, immune and cardiovascular function (By similarity). Specifically, plays an important role in neurogenic contraction of smooth muscle of the vas deferens, and therefore is essential for normal male reproductive function (By similarity). In addition, contributes to smooth muscle contractions of the urinary bladder (By similarity). On platelets, contributes to platelet activation and aggregation and thereby, also to thrombosis (By similarity). On neutrophils, it is involved in chemotaxis and in mitigating the activation of circulating cells (PubMed:19635923)