Gene name: TPMT

Uniprot entry:

P51580

Protein names:

Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase)

Protein sequence:

1_MDGTR 6_ TSLDI 11_ EEYSD 16_ TEVQK 21_ NQVLT 26_ LEEWQ 31_ DKWVN 36_ GKTAF 41_ HQEQG 46_ HQLLK 51_ KHLDT 56_ FLKGK 61_ SGLRV 66_ FFPLC 71_ GKAVE 76_ MKWFA 81_ DRGHS 86_ VVGVE 91_ ISELG 96_ IQEFF 101_ TEQNL 106_ SYSEE 111_ PITEI 116_ PGTKV 121_ FKSSS 126_ GNISL 131_ YCCSI 136_ FDLPR 141_ TNIGK 146_ FDMIW 151_ DRGAL 156_ VAINP 161_ GDRKC 166_ YADTM 171_ FSLLG 176_ KKFQY 181_ LLCVL 186_ SYDPT 191_ KHPGP 196_ PFYVP 201_ HAEIE 206_ RLFGK 211_ ICNIR 216_ CLEKV 221_ DAFEE 226_ RHKSW 231_ GIDCL 236_FEKLY

Protein annotations

Protein functions:

1: Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor (PubMed:18484748, PubMed:657528). TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified