Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein)
1_MPIGS 6_ KERPT 11_ FFEIF 16_ KTRCN 21_ KADLG 26_ PISLN 31_ WFEEL 36_ SSEAP 41_ PYNSE 46_ PAEES 51_ EHKNN 56_ NYEPN 61_ LFKTP 66_ QRKPS 71_ YNQLA 76_ STPII 81_ FKEQG 86_ LTLPL 91_ YQSPV 96_ KELDK 101_ FKLDL 106_ GRNVP 111_ NSRHK 116_ SLRTV 121_ KTKMD 126_ QADDV 131_ SCPLL 136_ NSCLS 141_ ESPVV 146_ LQCTH 151_ VTPQR 156_ DKSVV 161_ CGSLF 166_ HTPKF 171_ VKGRQ 176_ TPKHI 181_ SESLG 186_ AEVDP 191_ DMSWS 196_ SSLAT 201_ PPTLS 206_ STVLI 211_ VRNEE 216_ ASETV 221_ FPHDT 226_ TANVK 231_ SYFSN 236_ HDESL 241_ KKNDR 246_ FIASV 251_ TDSEN 256_ TNQRE 261_ AASHG 266_ FGKTS 271_ GNSFK 276_ VNSCK 281_ DHIGK 286_ SMPNV 291_ LEDEV 296_ YETVV 301_ DTSEE 306_ DSFSL 311_ CFSKC 316_ RTKNL 321_ QKVRT 326_ SKTRK 331_ KIFHE 336_ ANADE 341_ CEKSK 346_ NQVKE 351_ KYSFV 356_ SEVEP 361_ NDTDP 366_ LDSNV 371_ ANQKP 376_ FESGS 381_ DKISK 386_ EVVPS 391_ LACEW 396_ SQLTL 401_ SGLNG 406_ AQMEK 411_ IPLLH 416_ ISSCD 421_ QNISE 426_ KDLLD 431_ TENKR 436_ KKDFL 441_ TSENS 446_ LPRIS 451_ SLPKS 456_ EKPLN 461_ EETVV 466_ NKRDE 471_ EQHLE 476_ SHTDC 481_ ILAVK 486_ QAISG 491_ TSPVA 496_ SSFQG 501_ IKKSI 506_ FRIRE 511_ SPKET 516_ FNASF 521_ SGHMT 526_ DPNFK 531_ KETEA 536_ SESGL 541_ EIHTV 546_ CSQKE 551_ DSLCP 556_ NLIDN 561_ GSWPA 566_ TTTQN 571_ SVALK 576_ NAGLI 581_ STLKK 586_ KTNKF 591_ IYAIH 596_ DETSY 601_ KGKKI 606_ PKDQK 611_ SELIN 616_ CSAQF 621_ EANAF 626_ EAPLT 631_ FANAD 636_ SGLLH 641_ SSVKR 646_ SCSQN 651_ DSEEP 656_ TLSLT 661_ SSFGT 666_ ILRKC 671_ SRNET 676_ CSNNT 681_ VISQD 686_ LDYKE 691_ AKCNK 696_ EKLQL 701_ FITPE 706_ ADSLS 711_ CLQEG 716_ QCEND 721_ PKSKK 726_ VSDIK 731_ EEVLA 736_ AACHP 741_ VQHSK 746_ VEYSD 751_ TDFQS 756_ QKSLL 761_ YDHEN 766_ ASTLI 771_ LTPTS 776_ KDVLS 781_ NLVMI 786_ SRGKE 791_ SYKMS 796_ DKLKG 801_ NNYES 806_ DVELT 811_ KNIPM 816_ EKNQD 821_ VCALN 826_ ENYKN 831_ VELLP 836_ PEKYM 841_ RVASP 846_ SRKVQ 851_ FNQNT 856_ NLRVI 861_ QKNQE 866_ ETTSI 871_ SKITV 876_ NPDSE 881_ ELFSD 886_ NENNF 891_ VFQVA 896_ NERNN 901_ LALGN 906_ TKELH 911_ ETDLT 916_ CVNEP 921_ IFKNS 926_ TMVLY 931_ GDTGD 936_ KQATQ 941_ VSIKK 946_ DLVYV 951_ LAEEN 956_ KNSVK 961_ QHIKM 966_ TLGQD 971_ LKSDI 976_ SLNID 981_ KIPEK 986_ NNDYM 991_ NKWAG 996_ LLGPI 1001_ SNHSF 1006_ GGSFR 1011_ TASNK 1016_ EIKLS 1021_ EHNIK 1026_ KSKMF 1031_ FKDIE 1036_ EQYPT 1041_ SLACV 1046_ EIVNT 1051_ LALDN 1056_ QKKLS 1061_ KPQSI 1066_ NTVSA 1071_ HLQSS 1076_ VVVSD 1081_ CKNSH 1086_ ITPQM 1091_ LFSKQ 1096_ DFNSN 1101_ HNLTP 1106_ SQKAE 1111_ ITELS 1116_ TILEE 1121_ SGSQF 1126_ EFTQF 1131_ RKPSY 1136_ ILQKS 1141_ TFEVP 1146_ ENQMT 1151_ ILKTT 1156_ SEECR 1161_ DADLH 1166_ VIMNA 1171_ PSIGQ 1176_ VDSSK 1181_ QFEGT 1186_ VEIKR 1191_ KFAGL 1196_ LKNDC 1201_ NKSAS 1206_ GYLTD 1211_ ENEVG 1216_ FRGFY 1221_ SAHGT 1226_ KLNVS 1231_ TEALQ 1236_ KAVKL 1241_ FSDIE 1246_ NISEE 1251_ TSAEV 1256_ HPISL 1261_ SSSKC 1266_ HDSVV 1271_ SMFKI 1276_ ENHND 1281_ KTVSE 1286_ KNNKC 1291_ QLILQ 1296_ NNIEM 1301_ TTGTF 1306_ VEEIT 1311_ ENYKR 1316_ NTENE 1321_ DNKYT 1326_ AASRN 1331_ SHNLE 1336_ FDGSD 1341_ SSKND 1346_ TVCIH 1351_ KDETD 1356_ LLFTD 1361_ QHNIC 1366_ LKLSG 1371_ QFMKE 1376_ GNTQI 1381_ KEDLS 1386_ DLTFL 1391_ EVAKA 1396_ QEACH 1401_ GNTSN 1406_ KEQLT 1411_ ATKTE 1416_ QNIKD 1421_ FETSD 1426_ TFFQT 1431_ ASGKN 1436_ ISVAK 1441_ ESFNK 1446_ IVNFF 1451_ DQKPE 1456_ ELHNF 1461_ SLNSE 1466_ LHSDI 1471_ RKNKM 1476_ DILSY 1481_ EETDI 1486_ VKHKI 1491_ LKESV 1496_ PVGTG 1501_ NQLVT 1506_ FQGQP 1511_ ERDEK 1516_ IKEPT 1521_ LLGFH 1526_ TASGK 1531_ KVKIA 1536_ KESLD 1541_ KVKNL 1546_ FDEKE 1551_ QGTSE 1556_ ITSFS 1561_ HQWAK 1566_ TLKYR 1571_ EACKD 1576_ LELAC 1581_ ETIEI 1586_ TAAPK 1591_ CKEMQ 1596_ NSLNN 1601_ DKNLV 1606_ SIETV 1611_ VPPKL 1616_ LSDNL 1621_ CRQTE 1626_ NLKTS 1631_ KSIFL 1636_ KVKVH 1641_ ENVEK 1646_ ETAKS 1651_ PATCY 1656_ TNQSP 1661_ YSVIE 1666_ NSALA 1671_ FYTSC 1676_ SRKTS 1681_ VSQTS 1686_ LLEAK 1691_ KWLRE 1696_ GIFDG 1701_ QPERI 1706_ NTADY 1711_ VGNYL 1716_ YENNS 1721_ NSTIA 1726_ ENDKN 1731_ HLSEK 1736_ QDTYL 1741_ SNSSM 1746_ SNSYS 1751_ YHSDE 1756_ VYNDS 1761_ GYLSK 1766_ NKLDS 1771_ GIEPV 1776_ LKNVE 1781_ DQKNT 1786_ SFSKV 1791_ ISNVK 1796_ DANAY 1801_ PQTVN 1806_ EDICV 1811_ EELVT 1816_ SSSPC 1821_ KNKNA 1826_ AIKLS 1831_ ISNSN 1836_ NFEVG 1841_ PPAFR 1846_ IASGK 1851_ IVCVS 1856_ HETIK 1861_ KVKDI 1866_ FTDSF 1871_ SKVIK 1876_ ENNEN 1881_ KSKIC 1886_ QTKIM 1891_ AGCYE 1896_ ALDDS 1901_ EDILH 1906_ NSLDN 1911_ DECST 1916_ HSHKV 1921_ FADIQ 1926_ SEEIL 1931_ QHNQN 1936_ MSGLE 1941_ KVSKI 1946_ SPCDV 1951_ SLETS 1956_ DICKC 1961_ SIGKL 1966_ HKSVS 1971_ SANTC 1976_ GIFST 1981_ ASGKS 1986_ VQVSD 1991_ ASLQN 1996_ ARQVF 2001_ SEIED 2006_ STKQV 2011_ FSKVL 2016_ FKSNE 2021_ HSDQL 2026_ TREEN 2031_ TAIRT 2036_ PEHLI 2041_ SQKGF 2046_ SYNVV 2051_ NSSAF 2056_ SGFST 2061_ ASGKQ 2066_ VSILE 2071_ SSLHK 2076_ VKGVL 2081_ EEFDL 2086_ IRTEH 2091_ SLHYS 2096_ PTSRQ 2101_ NVSKI 2106_ LPRVD 2111_ KRNPE 2116_ HCVNS 2121_ EMEKT 2126_ CSKEF 2131_ KLSNN 2136_ LNVEG 2141_ GSSEN 2146_ NHSIK 2151_ VSPYL 2156_ SQFQQ 2161_ DKQQL 2166_ VLGTK 2171_ VSLVE 2176_ NIHVL 2181_ GKEQA 2186_ SPKNV 2191_ KMEIG 2196_ KTETF 2201_ SDVPV 2206_ KTNIE 2211_ VCSTY 2216_ SKDSE 2221_ NYFET 2226_ EAVEI 2231_ AKAFM 2236_ EDDEL 2241_ TDSKL 2246_ PSHAT 2251_ HSLFT 2256_ CPENE 2261_ EMVLS 2266_ NSRIG 2271_ KRRGE 2276_ PLILV 2281_ GEPSI 2286_ KRNLL 2291_ NEFDR 2296_ IIENQ 2301_ EKSLK 2306_ ASKST 2311_ PDGTI 2316_ KDRRL 2321_ FMHHV 2326_ SLEPI 2331_ TCVPF 2336_ RTTKE 2341_ RQEIQ 2346_ NPNFT 2351_ APGQE 2356_ FLSKS 2361_ HLYEH 2366_ LTLEK 2371_ SSSNL 2376_ AVSGH 2381_ PFYQV 2386_ SATRN 2391_ EKMRH 2396_ LITTG 2401_ RPTKV 2406_ FVPPF 2411_ KTKSH 2416_ FHRVE 2421_ QCVRN 2426_ INLEE 2431_ NRQKQ 2436_ NIDGH 2441_ GSDDS 2446_ KNKIN 2451_ DNEIH 2456_ QFNKN 2461_ NSNQA 2466_ VAVTF 2471_ TKCEE 2476_ EPLDL 2481_ ITSLQ 2486_ NARDI 2491_ QDMRI 2496_ KKKQR 2501_ QRVFP 2506_ QPGSL 2511_ YLAKT 2516_ STLPR 2521_ ISLKA 2526_ AVGGQ 2531_ VPSAC 2536_ SHKQL 2541_ YTYGV 2546_ SKHCI 2551_ KINSK 2556_ NAESF 2561_ QFHTE 2566_ DYFGK 2571_ ESLWT 2576_ GKGIQ 2581_ LADGG 2586_ WLIPS 2591_ NDGKA 2596_ GKEEF 2601_ YRALC 2606_ DTPGV 2611_ DPKLI 2616_ SRIWV 2621_ YNHYR 2626_ WIIWK 2631_ LAAME 2636_ CAFPK 2641_ EFANR 2646_ CLSPE 2651_ RVLLQ 2656_ LKYRY 2661_ DTEID 2666_ RSRRS 2671_ AIKKI 2676_ MERDD 2681_ TAAKT 2686_ LVLCV 2691_ SDIIS 2696_ LSANI 2701_ SETSS 2706_ NKTSS 2711_ ADTQK 2716_ VAIIE 2721_ LTDGW 2726_ YAVKA 2731_ QLDPP 2736_ LLAVL 2741_ KNGRL 2746_ TVGQK 2751_ IILHG 2756_ AELVG 2761_ SPDAC 2766_ TPLEA 2771_ PESLM 2776_ LKISA 2781_ NSTRP 2786_ ARWYT 2791_ KLGFF 2796_ PDPRP 2801_ FPLPL 2806_ SSLFS 2811_ DGGNV 2816_ GCVDV 2821_ IIQRA 2826_ YPIQW 2831_ MEKTS 2836_ SGLYI 2841_ FRNER 2846_ EEEKE 2851_ AAKYV 2856_ EAQQK 2861_ RLEAL 2866_ FTKIQ 2871_ EEFEE 2876_ HEENT 2881_ TKPYL 2886_ PSRAL 2891_ TRQQV 2896_ RALQD 2901_ GAELY 2906_ EAVKN 2911_ AADPA 2916_ YLEGY 2921_ FSEEQ 2926_ LRALN 2931_ NHRQM 2936_ LNDKK 2941_ QAQIQ 2946_ LEIRK 2951_ AMESA 2956_ EQKEQ 2961_ GLSRD 2966_ VTTVW 2971_ KLRIV 2976_ SYSKK 2981_ EKDSV 2986_ ILSIW 2991_ RPSSD 2996_ LYSLL 3001_ TEGKR 3006_ YRIYH 3011_ LATSK 3016_ SKSKS 3021_ ERANI 3026_ QLAAT 3031_ KKTQY 3036_ QQLPV 3041_ SDEIL 3046_ FQIYQ 3051_ PREPL 3056_ HFSKF 3061_ LDPDF 3066_ QPSCS 3071_ EVDLI 3076_ GFVVS 3081_ VVKKT 3086_ GLAPF 3091_ VYLSD 3096_ ECYNL 3101_ LAIKF 3106_ WIDLN 3111_ EDIIK 3116_ PHMLI 3121_ AASNL 3126_ QWRPE 3131_ SKSGL 3136_ LTLFA 3141_ GDFSV 3146_ FSASP 3151_ KEGHF 3156_ QETFN 3161_ KMKNT 3166_ VENID 3171_ ILCNE 3176_ AENKL 3181_ MHILH 3186_ ANDPK 3191_ WSTPT 3196_ KDCTS 3201_ GPYTA 3206_ QIIPG 3211_ TGNKL 3216_ LMSSP 3221_ NCEIY 3226_ YQSPL 3231_ SLCMA 3236_ KRKSV 3241_ STPVS 3246_ AQMTS 3251_ KSCKG 3256_ EKEID 3261_ DQKNC 3266_ KKRRA 3271_ LDFLS 3276_ RLPLP 3281_ PPVSP 3286_ ICTFV 3291_ SPAAQ 3296_ KAFQP 3301_ PRSCG 3306_ TKYET 3311_ PIKKK 3316_ ELNSP 3321_ QMTPF 3326_ KKFNE 3331_ ISLLE 3336_ SNSIA 3341_ DEELA 3346_ LINTQ 3351_ ALLSG 3356_ STGEK 3361_ QFISV 3366_ SESTR 3371_ TAPTS 3376_ SEDYL 3381_ RLKRR 3386_ CTTSL 3391_ IKEQE 3396_ SSQAS 3401_ TEECE 3406_ KNKQD 3411_TITTK
1: Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180)