Cytochrome P450 2J2 (EC 1.14.14.-) (Albendazole monooxygenase (hydroxylating)) (EC 1.14.14.74) (Albendazole monooxygenase (sulfoxide-forming)) (EC 1.14.14.73) (Arachidonic acid epoxygenase) (CYPIIJ2) (Hydroperoxy icosatetraenoate isomerase) (EC 5.4.4.7)
1_MLAAM 6_ GSLAA 11_ ALWAV 16_ VHPRT 21_ LLLGT 26_ VAFLL 31_ AADFL 36_ KRRRP 41_ KNYPP 46_ GPWRL 51_ PFLGN 56_ FFLVD 61_ FEQSH 66_ LEVQL 71_ FVKKY 76_ GNLFS 81_ LELGD 86_ ISAVL 91_ ITGLP 96_ LIKEA 101_ LIHMD 106_ QNFGN 111_ RPVTP 116_ MREHI 121_ FKKNG 126_ LIMSS 131_ GQAWK 136_ EQRRF 141_ TLTAL 146_ RNFGL 151_ GKKSL 156_ EERIQ 161_ EEAQH 166_ LTEAI 171_ KEENG 176_ QPFDP 181_ HFKIN 186_ NAVSN 191_ IICSI 196_ TFGER 201_ FEYQD 206_ SWFQQ 211_ LLKLL 216_ DEVTY 221_ LEASK 226_ TCQLY 231_ NVFPW 236_ IMKFL 241_ PGPHQ 246_ TLFSN 251_ WKKLK 256_ LFVSH 261_ MIDKH 266_ RKDWN 271_ PAETR 276_ DFIDA 281_ YLKEM 286_ SKHTG 291_ NPTSS 296_ FHEEN 301_ LICST 306_ LDLFF 311_ AGTET 316_ TSTTL 321_ RWALL 326_ YMALY 331_ PEIQE 336_ KVQAE 341_ IDRVI 346_ GQGQQ 351_ PSTAA 356_ RESMP 361_ YTNAV 366_ IHEVQ 371_ RMGNI 376_ IPLNV 381_ PREVT 386_ VDTTL 391_ AGYHL 396_ PKGTM 401_ ILTNL 406_ TALHR 411_ DPTEW 416_ ATPDT 421_ FNPDH 426_ FLENG 431_ QFKKR 436_ EAFMP 441_ FSIGK 446_ RACLG 451_ EQLAR 456_ TELFI 461_ FFTSL 466_ MQKFT 471_ FRPPN 476_ NEKLS 481_ LKFRM 486_ GITIS 491_ PVSHR 496_LCAVP
1: A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) in the cardiovascular system (PubMed:19965576, PubMed:8631948). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:19965576, PubMed:8631948). Catalyzes the epoxidation of double bonds of PUFA (PubMed:19965576, PubMed:8631948). Converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EpETrE), likely playing a major role in the epoxidation of endogenous cardiac arachidonic acid pools (PubMed:8631948). In endothelial cells, participates in eicosanoids metabolism by converting hydroperoxide species into hydroxy epoxy metabolites. In combination with 15-lipoxygenase metabolizes arachidonic acid and converts hydroperoxyicosatetraenoates (HpETEs) into hydroxy epoxy eicosatrienoates (HEETs), which are precursors of vasodilatory trihydroxyicosatrienoic acids (THETAs). This hydroperoxide isomerase activity is NADPH- and O2-independent (PubMed:19737933). Catalyzes the monooxygenation of a various xenobiotics, such as danazol, amiodarone, terfenadine, astemizole, thioridazine, tamoxifen, cyclosporin A and nabumetone (PubMed:19923256). Catalyzes hydroxylation of the anthelmintics albendazole and fenbendazole (PubMed:23959307). Catalyzes the sulfoxidation of fenbedazole (PubMed:19923256)