Gene name: MECP2

Uniprot entry:

P51608

Protein names:

Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2)

Protein sequence:

1_MVAGM 6_ LGLRE 11_ EKSED 16_ QDLQG 21_ LKDKP 26_ LKFKK 31_ VKKDK 36_ KEEKE 41_ GKHEP 46_ VQPSA 51_ HHSAE 56_ PAEAG 61_ KAETS 66_ EGSGS 71_ APAVP 76_ EASAS 81_ PKQRR 86_ SIIRD 91_ RGPMY 96_ DDPTL 101_ PEGWT 106_ RKLKQ 111_ RKSGR 116_ SAGKY 121_ DVYLI 126_ NPQGK 131_ AFRSK 136_ VELIA 141_ YFEKV 146_ GDTSL 151_ DPNDF 156_ DFTVT 161_ GRGSP 166_ SRREQ 171_ KPPKK 176_ PKSPK 181_ APGTG 186_ RGRGR 191_ PKGSG 196_ TTRPK 201_ AATSE 206_ GVQVK 211_ RVLEK 216_ SPGKL 221_ LVKMP 226_ FQTSP 231_ GGKAE 236_ GGGAT 241_ TSTQV 246_ MVIKR 251_ PGRKR 256_ KAEAD 261_ PQAIP 266_ KKRGR 271_ KPGSV 276_ VAAAA 281_ AEAKK 286_ KAVKE 291_ SSIRS 296_ VQETV 301_ LPIKK 306_ RKTRE 311_ TVSIE 316_ VKEVV 321_ KPLLV 326_ STLGE 331_ KSGKG 336_ LKTCK 341_ SPGRK 346_ SKESS 351_ PKGRS 356_ SSASS 361_ PPKKE 366_ HHHHH 371_ HHSES 376_ PKAPV 381_ PLLPP 386_ LPPPP 391_ PEPES 396_ SEDPT 401_ SPPEP 406_ QDLSS 411_ SVCKE 416_ EKMPR 421_ GGSLE 426_ SDGCP 431_ KEPAK 436_ TQPAV 441_ ATAAT 446_ AAEKY 451_ KHRGE 456_ GERKD 461_ IVSSS 466_ MPRPN 471_ REEPV 476_ DSRTP 481_VTERV

Protein annotations

Protein functions:

1: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC)