Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6]
1_MASAV 6_ SPANL 11_ PAVLL 16_ QPRWK 21_ RVVGW 26_ SGPVP 31_ RPRHG 36_ HRAVA 41_ IKELI 46_ VVFGG 51_ GNEGI 56_ VDELH 61_ VYNTA 66_ TNQWF 71_ IPAVR 76_ GDIPP 81_ GCAAY 86_ GFVCD 91_ GTRLL 96_ VFGGM 101_ VEYGK 106_ YSNDL 111_ YELQA 116_ SRWEW 121_ KRLKA 126_ KTPKN 131_ GPPPC 136_ PRLGH 141_ SFSLV 146_ GNKCY 151_ LFGGL 156_ ANDSE 161_ DPKNN 166_ IPRYL 171_ NDLYI 176_ LELRP 181_ GSGVV 186_ AWDIP 191_ ITYGV 196_ LPPPR 201_ ESHTA 206_ VVYTE 211_ KDNKK 216_ SKLVI 221_ YGGMS 226_ GCRLG 231_ DLWTL 236_ DIDTL 241_ TWNKP 246_ SLSGV 251_ APLPR 256_ SLHSA 261_ TTIGN 266_ KMYVF 271_ GGWVP 276_ LVMDD 281_ VKVAT 286_ HEKEW 291_ KCTNT 296_ LACLN 301_ LDTMA 306_ WETIL 311_ MDTLE 316_ DNIPR 321_ ARAGH 326_ CAVAI 331_ NTRLY 336_ IWSGR 341_ DGYRK 346_ AWNNQ 351_ VCCKD 356_ LWYLE 361_ TEKPP 366_ PPARV 371_ QLVRA 376_ NTNSL 381_ EVSWG 386_ AVATA 391_ DSYLL 396_ QLQKY 401_ DIPAT 406_ AATAT 411_ SPTPN 416_ PVPSV 421_ PANPP 426_ KSPAP 431_ AAAAP 436_ AVQPL 441_ TQVGI 446_ TLLPQ 451_ AAPAP 456_ PTTTT 461_ IQVLP 466_ TVPGS 471_ SISVP 476_ TAART 481_ QGVPA 486_ VLKVT 491_ GPQAT 496_ TGTPL 501_ VTMRP 506_ ASQAG 511_ KAPVT 516_ VTSLP 521_ AGVRM 526_ VVPTQ 531_ SAQGT 536_ VIGSS 541_ PQMSG 546_ MAALA 551_ AAAAA 556_ TQKIP 561_ PSSAP 566_ TVLSV 571_ PAGTT 576_ IVKTM 581_ AVTPG 586_ TTTLP 591_ ATVKV 596_ ASSPV 601_ MVSNP 606_ ATRML 611_ KTAAA 616_ QVGTS 621_ VSSAT 626_ NTSTR 631_ PIITV 636_ HKSGT 641_ VTVAQ 646_ QAQVV 651_ TTVVG 656_ GVTKT 661_ ITLVK 666_ SPISV 671_ PGGSA 676_ LISNL 681_ GKVMS 686_ VVQTK 691_ PVQTS 696_ AVTGQ 701_ ASTGP 706_ VTQII 711_ QTKGP 716_ LPAGT 721_ ILKLV 726_ TSADG 731_ KPTTI 736_ ITTTQ 741_ ASGAG 746_ TKPTI 751_ LGISS 756_ VSPST 761_ TKPGT 766_ TTIIK 771_ TIPMS 776_ AIITQ 781_ AGATG 786_ VTSSP 791_ GIKSP 796_ ITIIT 801_ TKVMT 806_ SGTGA 811_ PAKII 816_ TAVPK 821_ IATGH 826_ GQQGV 831_ TQVVL 836_ KGAPG 841_ QPGTI 846_ LRTVP 851_ MGGVR 856_ LVTPV 861_ TVSAV 866_ KPAVT 871_ TLVVK 876_ GTTGV 881_ TTLGT 886_ VTGTV 891_ STSLA 896_ GAGGH 901_ STSAS 906_ LATPI 911_ TTLGT 916_ IATLS 921_ SQVIN 926_ PTAIT 931_ VSAAQ 936_ TTLTA 941_ AGGLT 946_ TPTIT 951_ MQPVS 956_ QPTQV 961_ TLITA 966_ PSGVE 971_ AQPVH 976_ DLPVS 981_ ILASP 986_ TTEQP 991_ TATVT 996_ IADSG 1001_ QGDVQ 1006_ PGTVT 1011_ LVCSN 1016_ PPCET 1021_ HETGT 1026_ TNTAT 1031_ TTVVA 1036_ NLGGH 1041_ PQPTQ 1046_ VQFVC 1051_ DRQEA 1056_ AASLV 1061_ TSTVG 1066_ QQNGS 1071_ VVRVC 1076_ SNPPC 1081_ ETHET 1086_ GTTNT 1091_ ATTAT 1096_ SNMAG 1101_ QHGCS 1106_ NPPCE 1111_ THETG 1116_ TTNTA 1121_ TTAMS 1126_ SVGAN 1131_ HQRDA 1136_ RRACA 1141_ AGTPA 1146_ VIRIS 1151_ VATGA 1156_ LEAAQ 1161_ GSKSQ 1166_ CQTRQ 1171_ TSATS 1176_ TTMTV 1181_ MATGA 1186_ PCSAG 1191_ PLLGP 1196_ SMARE 1201_ PGGRS 1206_ PAFVQ 1211_ LAPLS 1216_ SKVRL 1221_ SSPSI 1226_ KDLPA 1231_ GRHSH 1236_ AVSTA 1241_ AMTRS 1246_ SVGAG 1251_ EPRMA 1256_ PVCES 1261_ LQGGS 1266_ PSTTV 1271_ TVTAL 1276_ EALLC 1281_ PSATV 1286_ TQVCS 1291_ NPPCE 1296_ THETG 1301_ TTNTA 1306_ TTSNA 1311_ GSAQR 1316_ VCSNP 1321_ PCETH 1326_ ETGTT 1331_ HTATT 1336_ ATSNG 1341_ GTGQP 1346_ EGGQQ 1351_ PPAGR 1356_ PCETH 1361_ QTTST 1366_ GTTMS 1371_ VSVGA 1376_ LLPDA 1381_ TSSHR 1386_ TVESG 1391_ LEVAA 1396_ APSVT 1401_ PQAGT 1406_ ALLAP 1411_ FPTQR 1416_ VCSNP 1421_ PCETH 1426_ ETGTT 1431_ HTATT 1436_ VTSNM 1441_ SSNQD 1446_ PPPAA 1451_ SDQGE 1456_ VESTQ 1461_ GDSVN 1466_ ITSSS 1471_ AITTT 1476_ VSSTL 1481_ TRAVT 1486_ TVTQS 1491_ TPVPG 1496_ PSVPP 1501_ PEELQ 1506_ VSPGP 1511_ RQQLP 1516_ PRQLL 1521_ QSAST 1526_ ALMGE 1531_ SAEVL 1536_ SASQT 1541_ PELPA 1546_ AVDLS 1551_ STGEP 1556_ SSGQE 1561_ SAGSA 1566_ VVATV 1571_ VVQPP 1576_ PPTQS 1581_ EVDQL 1586_ SLPQE 1591_ LMAEA 1596_ QAGTT 1601_ TLMVT 1606_ GLTPE 1611_ ELAVT 1616_ AAAEA 1621_ AAQAA 1626_ ATEEA 1631_ QALAI 1636_ QAVLQ 1641_ AAQQA 1646_ VMGTG 1651_ EPMDT 1656_ SEAAA 1661_ TVTQA 1666_ ELGHL 1671_ SAEGQ 1676_ EGQAT 1681_ TIPIV 1686_ LTQQE 1691_ LAALV 1696_ QQQQL 1701_ QEAQA 1706_ QQQHH 1711_ HLPTE 1716_ ALAPA 1721_ DSLND 1726_ PAIES 1731_ NCLNE 1736_ LAGTV 1741_ PSTVA 1746_ LLPST 1751_ ATESL 1756_ APSNT 1761_ FVAPQ 1766_ PVVVA 1771_ SPAKL 1776_ QAAAT 1781_ LTEVA 1786_ NGIES 1791_ LGVKP 1796_ DLPPP 1801_ PSKAP 1806_ MKKEN 1811_ QWFDV 1816_ GVIKG 1821_ TNVMV 1826_ THYFL 1831_ PPDDA 1836_ VPSDD 1841_ DLGTV 1846_ PDYNQ 1851_ LKKQE 1856_ LQPGT 1861_ AYKFR 1866_ VAGIN 1871_ ACGRG 1876_ PFSEI 1881_ SAFKT 1886_ CLPGF 1891_ PGAPC 1896_ AIKIS 1901_ KSPDG 1906_ AHLTW 1911_ EPPSV 1916_ TSGKI 1921_ IEYSV 1926_ YLAIQ 1931_ SSQAG 1936_ GELKS 1941_ STPAQ 1946_ LAFMR 1951_ VYCGP 1956_ SPSCL 1961_ VQSSS 1966_ LSNAH 1971_ IDYTT 1976_ KPAII 1981_ FRIAA 1986_ RNEKG 1991_ YGPAT 1996_ QVRWL 2001_ QETSK 2006_ DSSGT 2011_ KPANK 2016_ RPMSS 2021_ PEMKS 2026_APKKS
1: Transcriptional coregulator (By similarity). Serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators (PubMed:26416877). Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity)
2: (Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes