Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1)
1_MAGGP 6_ GPGEP 11_ AAPGA 16_ QHFLY 21_ EVPPW 26_ VMCRF 31_ YKVMD 36_ ALEPA 41_ DWCQF 46_ AALIV 51_ RDQTE 56_ LRLCE 61_ RSGQR 66_ TASVL 71_ WPWIN 76_ RNARV 81_ ADLVH 86_ ILTHL 91_ QLLRA 96_ RDIIT 101_ AWHPP 106_ APLPS 111_ PGTTA 116_ PRPSS 121_ IPAPA 126_ EAEAW 131_ SPRKL 136_ PSSAS 141_ TFLSP 146_ AFPGS 151_ QTHSG 156_ PELGL 161_ VPSPA 166_ SLWPP 171_ PPSPA 176_ PSSTK 181_ PGPES 186_ SVSLL 191_ QGARP 196_ FPFCW 201_ PLCEI 206_ SRGTH 211_ NFSEE 216_ LKIGE 221_ GGFGC 226_ VYRAV 231_ MRNTV 236_ YAVKR 241_ LKENA 246_ DLEWT 251_ AVKQS 256_ FLTEV 261_ EQLSR 266_ FRHPN 271_ IVDFA 276_ GYCAQ 281_ NGFYC 286_ LVYGF 291_ LPNGS 296_ LEDRL 301_ HCQTQ 306_ ACPPL 311_ SWPQR 316_ LDILL 321_ GTARA 326_ IQFLH 331_ QDSPS 336_ LIHGD 341_ IKSSN 346_ VLLDE 351_ RLTPK 356_ LGDFG 361_ LARFS 366_ RFAGS 371_ SPSQS 376_ SMVAR 381_ TQTVR 386_ GTLAY 391_ LPEEY 396_ IKTGR 401_ LAVDT 406_ DTFSF 411_ GVVVL 416_ ETLAG 421_ QRAVK 426_ THGAR 431_ TKYLK 436_ DLVEE 441_ EAEEA 446_ GVALR 451_ STQST 456_ LQAGL 461_ AADAW 466_ AAPIA 471_ MQIYK 476_ KHLDP 481_ RPGPC 486_ PPELG 491_ LGLGQ 496_ LACCC 501_ LHRRA 506_ KRRPP 511_ MTQVY 516_ ERLEK 521_ LQAVV 526_ AGVPG 531_ HSEAA 536_ SCIPP 541_ SPQEN 546_ SYVSS 551_ TGRAH 556_ SGAAP 561_ WQPLA 566_ APSGA 571_ SAQAA 576_ EQLQR 581_ GPNQP 586_ VESDE 591_ SLGGL 596_ SAALR 601_ SWHLT 606_ PSCPL 611_ DPAPL 616_ REAGC 621_ PQGDT 626_ AGESS 631_ WGSGP 636_ GSRPT 641_ AVEGL 646_ ALGSS 651_ ASSSS 656_ EPPQI 661_ IINPA 666_ RQKMV 671_ QKLAL 676_ YEDGA 681_ LDSLQ 686_ LLSSS 691_ SLPGL 696_ GLEQD 701_ RQGPE 706_ESDEF
1: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3