Caveolin-2
1_MGLET 6_ EKADV 11_ QLFMD 16_ DDSYS 21_ HHSGL 26_ EYADP 31_ EKFAD 36_ SDQDR 41_ DPHRL 46_ NSHLK 51_ LGFED 56_ VIAEP 61_ VTTHS 66_ FDKVW 71_ ICSHA 76_ LFEIS 81_ KYVMY 86_ KFLTV 91_ FLAIP 96_ LAFIA 101_ GILFA 106_ TLSCL 111_ HIWIL 116_ MPFVK 121_ TCLMV 126_ LPSVQ 131_ TIWKS 136_ VTDVI 141_ IAPLC 146_ TSVGR 151_ CFSSV 156_SLQLS
1: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity)