Glypican-3 (GTR2-2) (Intestinal protein OCI-5) (MXR7) [Cleaved into: Glypican-3 alpha subunit; Glypican-3 beta subunit]
1_MAGTV 6_ RTACL 11_ VVAML 16_ LSLDF 21_ PGQAQ 26_ PPPPP 31_ PDATC 36_ HQVRS 41_ FFQRL 46_ QPGLK 51_ WVPET 56_ PVPGS 61_ DLQVC 66_ LPKGP 71_ TCCSR 76_ KMEEK 81_ YQLTA 86_ RLNME 91_ QLLQS 96_ ASMEL 101_ KFLII 106_ QNAAV 111_ FQEAF 116_ EIVVR 121_ HAKNY 126_ TNAMF 131_ KNNYP 136_ SLTPQ 141_ AFEFV 146_ GEFFT 151_ DVSLY 156_ ILGSD 161_ INVDD 166_ MVNEL 171_ FDSLF 176_ PVIYT 181_ QLMNP 186_ GLPDS 191_ ALDIN 196_ ECLRG 201_ ARRDL 206_ KVFGN 211_ FPKLI 216_ MTQVS 221_ KSLQV 226_ TRIFL 231_ QALNL 236_ GIEVI 241_ NTTDH 246_ LKFSK 251_ DCGRM 256_ LTRMW 261_ YCSYC 266_ QGLMM 271_ VKPCG 276_ GYCNV 281_ VMQGC 286_ MAGVV 291_ EIDKY 296_ WREYI 301_ LSLEE 306_ LVNGM 311_ YRIYD 316_ MENVL 321_ LGLFS 326_ TIHDS 331_ IQYVQ 336_ KNAGK 341_ LTTTI 346_ GKLCA 351_ HSQQR 356_ QYRSA 361_ YYPED 366_ LFIDK 371_ KVLKV 376_ AHVEH 381_ EETLS 386_ SRRRE 391_ LIQKL 396_ KSFIS 401_ FYSAL 406_ PGYIC 411_ SHSPV 416_ AENDT 421_ LCWNG 426_ QELVE 431_ RYSQK 436_ AARNG 441_ MKNQF 446_ NLHEL 451_ KMKGP 456_ EPVVS 461_ QIIDK 466_ LKHIN 471_ QLLRT 476_ MSMPK 481_ GRVLD 486_ KNLDE 491_ EGFES 496_ GDCGD 501_ DEDEC 506_ IGGSG 511_ DGMIK 516_ VKNQL 521_ RFLAE 526_ LAYDL 531_ DVDDA 536_ PGNSQ 541_ QATPK 546_ DNEIS 551_ TFHNL 556_ GNVHS 561_ PLKLL 566_ TSMAI 571_SVVCF
1: Cell surface proteoglycan (PubMed:14610063). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands (PubMed:16227623, PubMed:24496449). Positively regulates the non-canonical Wnt signaling pathway (By similarity). Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (By similarity). Inhibits the dipeptidyl peptidase activity of DPP4 (PubMed:17549790). Plays a role in limb patterning and skeletal development by controlling the cellular response to BMP4 (By similarity). Modulates the effects of growth factors BMP2, BMP7 and FGF7 on renal branching morphogenesis (By similarity). Required for coronary vascular development (By similarity). Plays a role in regulating cell movements during gastrulation (By similarity)