Peroxisomal multifunctional enzyme type 2 (MFE-2) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-bifunctional protein) (DBP) (Multifunctional protein 2) (MFP-2) (Short chain dehydrogenase/reductase family 8C member 1) [Cleaved into: (3R)-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12); Enoyl-CoA hydratase 2 (EC 4.2.1.107) (EC 4.2.1.119) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase)]
1_MGSPL 6_ RFDGR 11_ VVLVT 16_ GAGAG 21_ LGRAY 26_ ALAFA 31_ ERGAL 36_ VVVND 41_ LGGDF 46_ KGVGK 51_ GSLAA 56_ DKVVE 61_ EIRRR 66_ GGKAV 71_ ANYDS 76_ VEEGE 81_ KVVKT 86_ ALDAF 91_ GRIDV 96_ VVNNA 101_ GILRD 106_ RSFAR 111_ ISDED 116_ WDIIH 121_ RVHLR 126_ GSFQV 131_ TRAAW 136_ EHMKK 141_ QKYGR 146_ IIMTS 151_ SASGI 156_ YGNFG 161_ QANYS 166_ AAKLG 171_ LLGLA 176_ NSLAI 181_ EGRKS 186_ NIHCN 191_ TIAPN 196_ AGSRM 201_ TQTVM 206_ PEDLV 211_ EALKP 216_ EYVAP 221_ LVLWL 226_ CHESC 231_ EENGG 236_ LFEVG 241_ AGWIG 246_ KLRWE 251_ RTLGA 256_ IVRQK 261_ NHPMT 266_ PEAVK 271_ ANWKK 276_ ICDFE 281_ NASKP 286_ QSIQE 291_ STGSI 296_ IEVLS 301_ KIDSE 306_ GGVSA 311_ NHTSR 316_ ATSTA 321_ TSGFA 326_ GAIGQ 331_ KLPPF 336_ SYAYT 341_ ELEAI 346_ MYALG 351_ VGASI 356_ KDPKD 361_ LKFIY 366_ EGSSD 371_ FSCLP 376_ TFGVI 381_ IGQKS 386_ MMGGG 391_ LAEIP 396_ GLSIN 401_ FAKVL 406_ HGEQY 411_ LELYK 416_ PLPRA 421_ GKLKC 426_ EAVVA 431_ DVLDK 436_ GSGVV 441_ IIMDV 446_ YSYSE 451_ KELIC 456_ HNQFS 461_ LFLVG 466_ SGGFG 471_ GKRTS 476_ DKVKV 481_ AVAIP 486_ NRPPD 491_ AVLTD 496_ TTSLN 501_ QAALY 506_ RLSGD 511_ WNPLH 516_ IDPNF 521_ ASLAG 526_ FDKPI 531_ LHGLC 536_ TFGFS 541_ ARRVL 546_ QQFAD 551_ NDVSR 556_ FKAIK 561_ ARFAK 566_ PVYPG 571_ QTLQT 576_ EMWKE 581_ GNRIH 586_ FQTKV 591_ QETGD 596_ IVISN 601_ AYVDL 606_ APTSG 611_ TSAKT 616_ PSEGG 621_ KLQST 626_ FVFEE 631_ IGRRL 636_ KDIGP 641_ EVVKK 646_ VNAVF 651_ EWHIT 656_ KGGNI 661_ GAKWT 666_ IDLKS 671_ GSGKV 676_ YQGPA 681_ KGAAD 686_ TTIIL 691_ SDEDF 696_ MEVVL 701_ GKLDP 706_ QKAFF 711_ SGRLK 716_ ARGNI 721_ MLSQK 726_ LQMIL 731_KDYAK
1: Bifunctional enzyme acting on the peroxisomal fatty acid beta-oxidation pathway. Catalyzes two of the four reactions in fatty acid degradation: hydration of 2-enoyl-CoA (trans-2-enoyl-CoA) to produce (3R)-3-hydroxyacyl-CoA, and dehydrogenation of (3R)-3-hydroxyacyl-CoA to produce 3-ketoacyl-CoA (3-oxoacyl-CoA), which is further metabolized by SCPx. Can use straight-chain and branched-chain fatty acids, as well as bile acid intermediates as substrates