Neuronal membrane glycoprotein M6-a (M6a)
1_MEENM 6_ EEGQT 11_ QKGCF 16_ ECCIK 21_ CLGGI 26_ PYASL 31_ IATIL 36_ LYAGV 41_ ALFCG 46_ CGHEA 51_ LSGTV 56_ NILQT 61_ YFEMA 66_ RTAGD 71_ TLDVF 76_ TMIDI 81_ FKYVI 86_ YGIAA 91_ AFFVY 96_ GILLM 101_ VEGFF 106_ TTGAI 111_ KDLYG 116_ DFKIT 121_ TCGRC 126_ VSAWF 131_ IMLTY 136_ LFMLA 141_ WLGVT 146_ AFTSL 151_ PVYMY 156_ FNLWT 161_ ICRNT 166_ TLVEG 171_ ANLCL 176_ DLRQF 181_ GIVTI 186_ GEEKK 191_ ICTVS 196_ ENFLR 201_ MCEST 206_ ELNMT 211_ FHLFI 216_ VALAG 221_ AGAAV 226_ IAMVH 231_ YLMVL 236_ SANWA 241_ YVKDA 246_ CRMQK 251_ YEDIK 256_ SKEEQ 261_ ELHDI 266_ HSTRS 271_KERLN
1: Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor