C-C chemokine receptor type 4 (C-C CKR-4) (CC-CKR-4) (CCR-4) (CCR4) (K5-5) (CD antigen CD194)
1_MNPTD 6_ IADTT 11_ LDESI 16_ YSNYY 21_ LYESI 26_ PKPCT 31_ KEGIK 36_ AFGEL 41_ FLPPL 46_ YSLVF 51_ VFGLL 56_ GNSVV 61_ VLVLF 66_ KYKRL 71_ RSMTD 76_ VYLLN 81_ LAISD 86_ LLFVF 91_ SLPFW 96_ GYYAA 101_ DQWVF 106_ GLGLC 111_ KMISW 116_ MYLVG 121_ FYSGI 126_ FFVML 131_ MSIDR 136_ YLAIV 141_ HAVFS 146_ LRART 151_ LTYGV 156_ ITSLA 161_ TWSVA 166_ VFASL 171_ PGFLF 176_ STCYT 181_ ERNHT 186_ YCKTK 191_ YSLNS 196_ TTWKV 201_ LSSLE 206_ INILG 211_ LVIPL 216_ GIMLF 221_ CYSMI 226_ IRTLQ 231_ HCKNE 236_ KKNKA 241_ VKMIF 246_ AVVVL 251_ FLGFW 256_ TPYNI 261_ VLFLE 266_ TLVEL 271_ EVLQD 276_ CTFER 281_ YLDYA 286_ IQATE 291_ TLAFV 296_ HCCLN 301_ PIIYF 306_ FLGEK 311_ FRKYI 316_ LQLFK 321_ TCRGL 326_ FVLCQ 331_ YCGLL 336_ QIYSA 341_ DTPSS 346_ SYTQS 351_TMDHD
1: High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival