C-C chemokine receptor type 6 (C-C CKR-6) (CC-CKR-6) (CCR-6) (Chemokine receptor-like 3) (CKR-L3) (DRY6) (G-protein coupled receptor 29) (GPR-CY4) (GPRCY4) (LARC receptor) (CD antigen CD196)
1_MSGES 6_ MNFSD 11_ VFDSS 16_ EDYFV 21_ SVNTS 26_ YYSVD 31_ SEMLL 36_ CSLQE 41_ VRQFS 46_ RLFVP 51_ IAYSL 56_ ICVFG 61_ LLGNI 66_ LVVIT 71_ FAFYK 76_ KARSM 81_ TDVYL 86_ LNMAI 91_ ADILF 96_ VLTLP 101_ FWAVS 106_ HATGA 111_ WVFSN 116_ ATCKL 121_ LKGIY 126_ AINFN 131_ CGMLL 136_ LTCIS 141_ MDRYI 146_ AIVQA 151_ TKSFR 156_ LRSRT 161_ LPRSK 166_ IICLV 171_ VWGLS 176_ VIISS 181_ STFVF 186_ NQKYN 191_ TQGSD 196_ VCEPK 201_ YQTVS 206_ EPIRW 211_ KLLML 216_ GLELL 221_ FGFFI 226_ PLMFM 231_ IFCYT 236_ FIVKT 241_ LVQAQ 246_ NSKRH 251_ KAIRV 256_ IIAVV 261_ LVFLA 266_ CQIPH 271_ NMVLL 276_ VTAAN 281_ LGKMN 286_ RSCQS 291_ EKLIG 296_ YTKTV 301_ TEVLA 306_ FLHCC 311_ LNPVL 316_ YAFIG 321_ QKFRN 326_ YFLKI 331_ LKDLW 336_ CVRRK 341_ YKSSG 346_ FSCAG 351_ RYSEN 356_ ISRQT 361_ SETAD 366_NDNAS
1: Receptor for the C-C type chemokine CCL20 (PubMed:9169459). Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels (PubMed:20068036). Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins (PubMed:25585877). Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity (PubMed:25122636). Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects (PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/ memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma (PubMed:21376174). CCR6 is essential for the recruitment of both the pro-inflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for the normal migration of Th17 cells in Peyers-patches and other related tissue sites of the intestine and plays a role in regulating effector T-cell balance and distribution in inflamed intestine. Plays an important role in the coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for the formation of normal thymic natural regulatory T-cells (nTregs). Required for optimal differentiation of DN2 and DN3 thymocyte precursors. Essential for B-cell localization in the subepithelial dome of Peyers-patches and for efficient B-cell isotype switching to IgA in the Peyers-patches. Essential for appropriate anatomical distribution of memory B-cells in the spleen and for the secondary recall response of memory B-cells (By similarity). Positively regulates sperm motility and chemotaxis via its binding to CCL20 (PubMed:23765988)