Amyloid beta precursor like protein 1 (Amyloid beta (A4) precursor-like protein 1) (Amyloid-like protein 1) (APLP) (APLP-1) [Cleaved into: C30]
1_MGPAS 6_ PAARG 11_ LSRRP 16_ GQPPL 21_ PLLLP 26_ LLLLL 31_ LRAQP 36_ AIGSL 41_ AGGSP 46_ GAAEA 51_ PGSAQ 56_ VAGLC 61_ GRLTL 66_ HRDLR 71_ TGRWE 76_ PDPQR 81_ SRRCL 86_ RDPQR 91_ VLEYC 96_ RQMYP 101_ ELQIA 106_ RVEQA 111_ TQAIP 116_ MERWC 121_ GGSRS 126_ GSCAH 131_ PHHQV 136_ VPFRC 141_ LPGEF 146_ VSEAL 151_ LVPEG 156_ CRFLH 161_ QERMD 166_ QCESS 171_ TRRHQ 176_ EAQEA 181_ CSSQG 186_ LILHG 191_ SGMLL 196_ PCGSD 201_ RFRGV 206_ EYVCC 211_ PPPGT 216_ PDPSG 221_ TAVGD 226_ PSTRS 231_ WPPGS 236_ RVEGA 241_ EDEEE 246_ EESFP 251_ QPVDD 256_ YFVEP 261_ PQAEE 266_ EEETV 271_ PPPSS 276_ HTLAV 281_ VGKVT 286_ PTPRP 291_ TDGVD 296_ IYFGM 301_ PGEIS 306_ EHEGF 311_ LRAKM 316_ DLEER 321_ RMRQI 326_ NEVMR 331_ EWAMA 336_ DNQSK 341_ NLPKA 346_ DRQAL 351_ NEHFQ 356_ SILQT 361_ LEEQV 366_ SGERQ 371_ RLVET 376_ HATRV 381_ IALIN 386_ DQRRA 391_ ALEGF 396_ LAALQ 401_ ADPPQ 406_ AERVL 411_ LALRR 416_ YLRAE 421_ QKEQR 426_ HTLRH 431_ YQHVA 436_ AVDPE 441_ KAQQM 446_ RFQVH 451_ THLQV 456_ IEERV 461_ NQSLG 466_ LLDQN 471_ PHLAQ 476_ ELRPQ 481_ IQELL 486_ HSEHL 491_ GPSEL 496_ EAPAP 501_ GGSSE 506_ DKGGL 511_ QPPDS 516_ KDDTP 521_ MTLPK 526_ GSTEQ 531_ DAASP 536_ EKEKM 541_ NPLEQ 546_ YERKV 551_ NASVP 556_ RGFPF 561_ HSSEI 566_ QRDEL 571_ APAGT 576_ GVSRE 581_ AVSGL 586_ LIMGA 591_ GGGSL 596_ IVLSM 601_ LLLRR 606_ KKPYG 611_ AISHG 616_ VVEVD 621_ PMLTL 626_ EEQQL 631_ RELQR 636_ HGYEN 641_PTYRF
1: May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I
2: The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis