Ubiquitin carboxyl-terminal hydrolase 11 (EC 3.4.19.12) (Deubiquitinating enzyme 11) (Ubiquitin thioesterase 11) (Ubiquitin-specific-processing protease 11)
1_MAVAP 6_ RLFGG 11_ LCFRF 16_ RDQNP 21_ EVAVE 26_ GRLPI 31_ SHSCV 36_ GCRRE 41_ RTAMA 46_ TVAAN 51_ PAAAA 56_ AAVAA 61_ AAAVT 66_ EDREP 71_ QHEEL 76_ PGLDS 81_ QWRQI 86_ ENGES 91_ GRERP 96_ LRAGE 101_ SWFLV 106_ EKHWY 111_ KQWEA 116_ YVQGG 121_ DQDSS 126_ TFPGC 131_ INNAT 136_ LFQDE 141_ INWRL 146_ KEGLV 151_ EGEDY 156_ VLLPA 161_ AAWHY 166_ LVSWY 171_ GLEHG 176_ QPPIE 181_ RKVIE 186_ LPNIQ 191_ KVEVY 196_ PVELL 201_ LVRHN 206_ DLGKS 211_ HTVQF 216_ SHTDS 221_ IGLVL 226_ RTARE 231_ RFLVE 236_ PQEDT 241_ RLWAK 246_ NSEGS 251_ LDRLY 256_ DTHIT 261_ VLDAA 266_ LETGQ 271_ LIIME 276_ TRKKD 281_ GTWPS 286_ AQLHV 291_ MNNNM 296_ SEEDE 301_ DFKGQ 306_ PGICG 311_ LTNLG 316_ NTCFM 321_ NSALQ 326_ CLSNV 331_ PQLTE 336_ YFLNN 341_ CYLEE 346_ LNFRN 351_ PLGMK 356_ GEIAE 361_ AYADL 366_ VKQAW 371_ SGHHR 376_ SIVPH 381_ VFKNK 386_ VGHFA 391_ SQFLG 396_ YQQHD 401_ SQELL 406_ SFLLD 411_ GLHED 416_ LNRVK 421_ KKEYV 426_ ELCDA 431_ AGRPD 436_ QEVAQ 441_ EAWQN 446_ HKRRN 451_ DSVIV 456_ DTFHG 461_ LFKST 466_ LVCPD 471_ CGNVS 476_ VTFDP 481_ FCYLS 486_ VPLPI 491_ SHKRV 496_ LEVFF 501_ IPMDP 506_ RRKPE 511_ QHRLV 516_ VPKKG 521_ KISDL 526_ CVALS 531_ KHTGI 536_ SPERM 541_ MVADV 546_ FSHRF 551_ YKLYQ 556_ LEEPL 561_ SSILD 566_ RDDIF 571_ VYEVS 576_ GRIEA 581_ IEGSR 586_ EDIVV 591_ PVYLR 596_ ERTPA 601_ RDYNN 606_ SYYGL 611_ MLFGH 616_ PLLVS 621_ VPRDR 626_ FTWEG 631_ LYNVL 636_ MYRLS 641_ RYVTK 646_ PNSDD 651_ EDDGD 656_ EKEDD 661_ EEDKD 666_ DVPGP 671_ STGGS 676_ LRDPE 681_ PEQAG 686_ PSSGV 691_ TNRCP 696_ FLLDN 701_ CLGTS 706_ QWPPR 711_ RRRKQ 716_ LFTLQ 721_ TVNSN 726_ GTSDR 731_ TTSPE 736_ EVHAQ 741_ PYIAI 746_ DWEPE 751_ MKKRY 756_ YDEVE 761_ AEGYV 766_ KHDCV 771_ GYVMK 776_ KAPVR 781_ LQECI 786_ ELFTT 791_ VETLE 796_ KENPW 801_ YCPSC 806_ KQHQL 811_ ATKKL 816_ DLWML 821_ PEILI 826_ IHLKR 831_ FSYTK 836_ FSREK 841_ LDTLV 846_ EFPIR 851_ DLDFS 856_ EFVIQ 861_ PQNES 866_ NPELY 871_ KYDLI 876_ AVSNH 881_ YGGMR 886_ DGHYT 891_ TFACN 896_ KDSGQ 901_ WHYFD 906_ DNSVS 911_ PVNEN 916_ QIESK 921_ AAYVL 926_ FYQRQ 931_ DVARR 936_ LLSPA 941_ GSSGA 946_ PASPA 951_ CSSPP 956_SSEFM
1: Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains (PubMed:12084015, PubMed:15314155, PubMed:17897950, PubMed:19874889, PubMed:20233726, PubMed:24724799, PubMed:28992046). Inhibits the degradation of target proteins by the proteasome (PubMed:12084015). Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro) (PubMed:24724799). Plays a role in the regulation of pathways leading to NF-kappa-B activation (PubMed:17897950, PubMed:19874889). Plays a role in the regulation of DNA repair after double-stranded DNA breaks (PubMed:15314155, PubMed:20233726). Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex (PubMed:20601937). Promotes cell proliferation by deubiquitinating phosphorylated E2F1 (PubMed:28992046)