Potassium voltage-gated channel subfamily KQT member 1 (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1) (Voltage-gated potassium channel subunit Kv7.1)
1_MAAAS 6_ SPPRA 11_ ERKRW 16_ GWGRL 21_ PGARR 26_ GSAGL 31_ AKKCP 36_ FSLEL 41_ AEGGP 46_ AGGAL 51_ YAPIA 56_ PGAPG 61_ PAPPA 66_ SPAAP 71_ AAPPV 76_ ASDLG 81_ PRPPV 86_ SLDPR 91_ VSIYS 96_ TRRPV 101_ LARTH 106_ VQGRV 111_ YNFLE 116_ RPTGW 121_ KCFVY 126_ HFAVF 131_ LIVLV 136_ CLIFS 141_ VLSTI 146_ EQYAA 151_ LATGT 156_ LFWME 161_ IVLVV 166_ FFGTE 171_ YVVRL 176_ WSAGC 181_ RSKYV 186_ GLWGR 191_ LRFAR 196_ KPISI 201_ IDLIV 206_ VVASM 211_ VVLCV 216_ GSKGQ 221_ VFATS 226_ AIRGI 231_ RFLQI 236_ LRMLH 241_ VDRQG 246_ GTWRL 251_ LGSVV 256_ FIHRQ 261_ ELITT 266_ LYIGF 271_ LGLIF 276_ SSYFV 281_ YLAEK 286_ DAVNE 291_ SGRVE 296_ FGSYA 301_ DALWW 306_ GVVTV 311_ TTIGY 316_ GDKVP 321_ QTWVG 326_ KTIAS 331_ CFSVF 336_ AISFF 341_ ALPAG 346_ ILGSG 351_ FALKV 356_ QQKQR 361_ QKHFN 366_ RQIPA 371_ AASLI 376_ QTAWR 381_ CYAAE 386_ NPDSS 391_ TWKIY 396_ IRKAP 401_ RSHTL 406_ LSPSP 411_ KPKKS 416_ VVVKK 421_ KKFKL 426_ DKDNG 431_ VTPGE 436_ KMLTV 441_ PHITC 446_ DPPEE 451_ RRLDH 456_ FSVDG 461_ YDSSV 466_ RKSPT 471_ LLEVS 476_ MPHFM 481_ RTNSF 486_ AEDLD 491_ LEGET 496_ LLTPI 501_ THISQ 506_ LREHH 511_ RATIK 516_ VIRRM 521_ QYFVA 526_ KKKFQ 531_ QARKP 536_ YDVRD 541_ VIEQY 546_ SQGHL 551_ NLMVR 556_ IKELQ 561_ RRLDQ 566_ SIGKP 571_ SLFIS 576_ VSEKS 581_ KDRGS 586_ NTIGA 591_ RLNRV 596_ EDKVT 601_ QLDQR 606_ LALIT 611_ DMLHQ 616_ LLSLH 621_ GGSTP 626_ GSGGP 631_ PREGG 636_ AHITQ 641_ PCGSG 646_ GSVDP 651_ ELFLP 656_ SNTLP 661_ TYEQL 666_ TVPRR 671_GPDEG
1: Pore-forming subunit of the voltage-gated potassium (Kv) channel involved in the regulation of cardiomyocyte excitability and important in normal development and functions of myocardium, inner ear, stomach and colon (PubMed:10646604, PubMed:25441029). Associates with KCNE beta subunits that modulates current kinetics (PubMed:10646604, PubMed:11101505, PubMed:19687231, PubMed:8900283, PubMed:9108097, PubMed:9312006). Induces a voltage-dependent current by rapidly activating and slowly deactivating potassium-selective outward current (PubMed:10646604, PubMed:11101505, PubMed:25441029, PubMed:8900283, PubMed:9108097, PubMed:9312006). Also promotes a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation, participates in cardiac repolarization by associating with KCNE1 to form the I(Ks) cardiac potassium current that increases the amplitude and slows down the activation kinetics of outward potassium current I(Ks) (By similarity) (PubMed:10646604, PubMed:11101505, PubMed:8900283, PubMed:9108097, PubMed:9312006). Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current (PubMed:10713961). When associated with KCNE3, forms the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions (PubMed:10646604). This interaction with KCNE3 is reduced by 17beta-estradiol, resulting in the reduction of currents (By similarity). During conditions of increased substrate load, maintains the driving force for proximal tubular and intestinal sodium ions absorption, gastric acid secretion, and cAMP-induced jejunal chloride ions secretion (By similarity). Allows the provision of potassium ions to the luminal membrane of the secretory canaliculus in the resting state as well as during stimulated acid secretion (By similarity). When associated with KCNE2, forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed:11101505). When associated with KCNE4, inhibits voltage-gated potassium channel activity (PubMed:19687231). When associated with KCNE5, this complex only conducts current upon strong and continued depolarization (PubMed:12324418). Also forms a heterotetramer with KCNQ5; has a voltage-gated potassium channel activity (PubMed:24855057). Binds with phosphatidylinositol 4,5-bisphosphate (PubMed:25037568). KCNQ1-KCNE2 channel associates with Na(+)-coupled myo-inositol symporter in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability (By similarity)
2: Non-functional alone but modulatory when coexpressed with the full-length isoform 1