Chloride channel protein 2 (ClC-2)
1_MAAAA 6_ AEEGM 11_ EPRAL 16_ QYEQT 21_ LMYGR 26_ YTQDL 31_ GAFAK 36_ EEAAR 41_ IRLGG 46_ PEPWK 51_ GPPSS 56_ RAAPE 61_ LLEYG 66_ RSRCA 71_ RCRVC 76_ SVRCH 81_ KFLVS 86_ RVGED 91_ WIFLV 96_ LLGLL 101_ MALVS 106_ WVMDY 111_ AIAAC 116_ LQAQQ 121_ WMSRG 126_ LNTSI 131_ LLQYL 136_ AWVTY 141_ PVVLI 146_ TFSAG 151_ FTQIL 156_ APQAV 161_ GSGIP 166_ EMKTI 171_ LRGVV 176_ LKEYL 181_ TLKTF 186_ IAKVI 191_ GLTCA 196_ LGSGM 201_ PLGKE 206_ GPFVH 211_ IASMC 216_ AALLS 221_ KFLSL 226_ FGGIY 231_ ENESR 236_ NTEML 241_ AAACA 246_ VGVGC 251_ CFAAP 256_ IGGVL 261_ FSIEV 266_ TSTFF 271_ AVRNY 276_ WRGFF 281_ AATFS 286_ AFIFR 291_ VLAVW 296_ NRDEE 301_ TITAL 306_ FKTRF 311_ RLDFP 316_ FDLQE 321_ LPAFA 326_ VIGIA 331_ SGFGG 336_ ALFVY 341_ LNRKI 346_ VQVMR 351_ KQKTI 356_ NRFLM 361_ RKRLL 366_ FPALV 371_ TLLIS 376_ TLTFP 381_ PGFGQ 386_ FMAGQ 391_ LSQKE 396_ TLVTL 401_ FDNRT 406_ WVRQG 411_ LVEEL 416_ EPPST 421_ SQAWN 426_ PPRAN 431_ VFLTL 436_ VIFIL 441_ MKFWM 446_ SALAT 451_ TIPVP 456_ CGAFM 461_ PVFVI 466_ GAAFG 471_ RLVGE 476_ SMAAW 481_ FPDGI 486_ HTDSS 491_ TYRIV 496_ PGGYA 501_ VVGAA 506_ ALAGA 511_ VTHTV 516_ STAVI 521_ VFELT 526_ GQIAH 531_ ILPVM 536_ IAVIL 541_ ANAVA 546_ QSLQP 551_ SLYDS 556_ IIRIK 561_ KLPYL 566_ PELGW 571_ GRHQQ 576_ YRVRV 581_ EDIMV 586_ RDVPH 591_ VALSC 596_ TFRDL 601_ RLALH 606_ RTKGR 611_ MLALV 616_ ESPES 621_ MILLG 626_ SIERS 631_ QVVAL 636_ LGAQL 641_ SPARR 646_ RQHMQ 651_ ERRAT 656_ QTSPL 661_ SDQEG 666_ PPTPE 671_ ASVCF 676_ QVNTE 681_ DSAFP 686_ AARGE 691_ THKPL 696_ KPALK 701_ RGPSV 706_ TRNLG 711_ ESPTG 716_ SAESA 721_ GIALR 726_ SLFCG 731_ SPPPE 736_ AASEK 741_ LESCE 746_ KRKLK 751_ RVRIS 756_ LASDA 761_ DLEGE 766_ MSPEE 771_ ILEWE 776_ EQQLD 781_ EPVNF 786_ SDCKI 791_ DPAPF 796_ QLVER 801_ TSLHK 806_ THTIF 811_ SLLGV 816_ DHAYV 821_ TSIGR 826_ LIGIV 831_ TLKEL 836_ RKAIE 841_ GSVTA 846_ QGVKV 851_ RPPLA 856_ SFRDS 861_ ATSSS 866_ DTETT 871_ EVHAL 876_ WGPHS 881_ RHGLP 886_ REGSP 891_SDSDD
1: Voltage-gated and osmosensitive chloride channel. Forms a homodimeric channel where each subunit has its own ion conduction pathway. Conducts double-barreled currents controlled by two types of gates, two fast glutamate gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously. Displays inward rectification currents activated upon membrane hyperpolarization and extracellular hypotonicity (PubMed:16155254, PubMed:17567819, PubMed:19191339, PubMed:23632988, PubMed:29403011, PubMed:29403012, PubMed:36964785, PubMed:38345841). Contributes to chloride conductance involved in neuron excitability. In hippocampal neurons, generates a significant part of resting membrane conductance and provides an additional chloride efflux pathway to prevent chloride accumulation in dendrites upon GABA receptor activation. In glia, associates with the auxiliary subunit HEPACAM/GlialCAM at astrocytic processes and myelinated fiber tracts where it may regulate transcellular chloride flux buffering extracellular chloride and potassium concentrations (PubMed:19191339, PubMed:22405205, PubMed:23707145). Regulates aldosterone production in adrenal glands. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization, activation of voltage-gated calcium channels and increased expression of aldosterone synthase, the rate-limiting enzyme for aldosterone biosynthesis (PubMed:29403011, PubMed:29403012). Contributes to chloride conductance in retinal pigment epithelium involved in phagocytosis of shed photoreceptor outer segments and photoreceptor renewal (PubMed:36964785). Conducts chloride currents at the basolateral membrane of epithelial cells with a role in chloride reabsorption rather than secretion (By similarity) (PubMed:16155254). Permeable to small monovalent anions with chloride > thiocyanate > bromide > nitrate > iodide ion selectivity (By similarity) (PubMed:29403012)