H(+)/Cl(-) exchange transporter 3 (Chloride channel protein 3) (ClC-3) (Chloride transporter ClC-3)
1_MESEQ 6_ LFHRG 11_ YYRNS 16_ YNSIT 21_ SASSD 26_ EELLD 31_ GAGVI 36_ MDFQT 41_ SEDDN 46_ LLDGD 51_ TAVGT 56_ HYTMT 61_ NGGSI 66_ NSSTH 71_ LLDLL 76_ DEPIP 81_ GVGTY 86_ DDFHT 91_ IDWVR 96_ EKCKD 101_ RERHR 106_ RINSK 111_ KKESA 116_ WEMTK 121_ SLYDA 126_ WSGWL 131_ VVTLT 136_ GLASG 141_ ALAGL 146_ IDIAA 151_ DWMTD 156_ LKEGI 161_ CLSAL 166_ WYNHE 171_ QCCWG 176_ SNETT 181_ FEERD 186_ KCPQW 191_ KTWAE 196_ LIIGQ 201_ AEGPG 206_ SYIMN 211_ YIMYI 216_ FWALS 221_ FAFLA 226_ VSLVK 231_ VFAPY 236_ ACGSG 241_ IPEIK 246_ TILSG 251_ FIIRG 256_ YLGKW 261_ TLMIK 266_ TITLV 271_ LAVAS 276_ GLSLG 281_ KEGPL 286_ VHVAC 291_ CCGNI 296_ FSYLF 301_ PKYST 306_ NEAKK 311_ REVLS 316_ AASAA 321_ GVSVA 326_ FGAPI 331_ GGVLF 336_ SLEEV 341_ SYYFP 346_ LKTLW 351_ RSFFA 356_ ALVAA 361_ FVLRS 366_ INPFG 371_ NSRLV 376_ LFYVE 381_ YHTPW 386_ YLFEL 391_ FPFIL 396_ LGVFG 401_ GLWGA 406_ FFIRA 411_ NIAWC 416_ RRRKS 421_ TKFGK 426_ YPVLE 431_ VIIVA 436_ AITAV 441_ IAFPN 446_ PYTRL 451_ NTSEL 456_ IKELF 461_ TDCGP 466_ LESSS 471_ LCDYR 476_ NDMNA 481_ SKIVD 486_ DIPDR 491_ PAGIG 496_ VYSAI 501_ WQLCL 506_ ALIFK 511_ IIMTV 516_ FTFGI 521_ KVPSG 526_ LFIPS 531_ MAIGA 536_ IAGRI 541_ VGIAV 546_ EQLAY 551_ YHHDW 556_ FIFKE 561_ WCEVG 566_ ADCIT 571_ PGLYA 576_ MVGAA 581_ ACLGG 586_ VTRMT 591_ VSLVV 596_ IVFEL 601_ TGGLE 606_ YIVPL 611_ MAAVM 616_ TSKWV 621_ GDAFG 626_ REGIY 631_ EAHIR 636_ LNGYP 641_ FLDAK 646_ EEFTH 651_ TTLAA 656_ DVMRP 661_ RRNDP 666_ PLAVL 671_ TQDNM 676_ TVDDI 681_ ENMIN 686_ ETSYN 691_ GFPVI 696_ MSKES 701_ QRLVG 706_ FALRR 711_ DLTIA 716_ IESAR 721_ KKQEG 726_ IVGSS 731_ RVCFA 736_ QHTPS 741_ LPAES 746_ PRPLK 751_ LRSIL 756_ DMSPF 761_ TVTDH 766_ TPMEI 771_ VVDIF 776_ RKLGL 781_ RQCLV 786_ THNGR 791_ LLGII 796_ TKKDI 801_ LRHMA 806_ QTANQ 811_DPASI
1: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (PubMed:29845874). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (PubMed:29845874)
2: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons