H(+)/Cl(-) exchange transporter 4 (Chloride channel protein 4) (ClC-4) (Chloride transporter ClC-4)
1_MVNAG 6_ AMSGS 11_ GNLMD 16_ FLDEP 21_ FPDVG 26_ TYEDF 31_ HTIDW 36_ LREKS 41_ RDTDR 46_ HRKIT 51_ SKSKE 56_ SIWEF 61_ IKSLL 66_ DAWSG 71_ WVVML 76_ LIGLL 81_ AGTLA 86_ GVIDL 91_ AVDWM 96_ TDLKE 101_ GVCLS 106_ AFWYS 111_ HEQCC 116_ WTSNE 121_ TTFED 126_ RDKCP 131_ LWQKW 136_ SELLV 141_ NQSEG 146_ ASAYI 151_ LNYLM 156_ YILWA 161_ LLFAF 166_ LAVSL 171_ VRVFA 176_ PYACG 181_ SGIPE 186_ IKTIL 191_ SGFII 196_ RGYLG 201_ KWTLL 206_ IKTVT 211_ LVLVV 216_ SSGLS 221_ LGKEG 226_ PLVHV 231_ ACCCG 236_ NFFSS 241_ LFSKY 246_ SKNEG 251_ KRREV 256_ LSAAA 261_ AAGVS 266_ VAFGA 271_ PIGGV 276_ LFSLE 281_ EVSYY 286_ FPLKT 291_ LWRSF 296_ FAALV 301_ AAFTL 306_ RSINP 311_ FGNSR 316_ LVLFY 321_ VEYHT 326_ PWYMA 331_ ELFPF 336_ ILLGV 341_ FGGLW 346_ GTLFI 351_ RCNIA 356_ WCRRR 361_ KTTRL 366_ GKYPV 371_ LEVIV 376_ VTAIT 381_ AIIAY 386_ PNPYT 391_ RQSTS 396_ ELISE 401_ LFNDC 406_ GALES 411_ SQLCD 416_ YINDP 421_ NMTRP 426_ VDDIP 431_ DRPAG 436_ VGVYT 441_ AMWQL 446_ ALALI 451_ FKIVV 456_ TIFTF 461_ GMKIP 466_ SGLFI 471_ PSMAV 476_ GAIAG 481_ RMVGI 486_ GVEQL 491_ AYHHH 496_ DWIIF 501_ RNWCR 506_ PGADC 511_ VTPGL 516_ YAMVG 521_ AAACL 526_ GGVTR 531_ MTVSL 536_ VVIMF 541_ ELTGG 546_ LEYIV 551_ PLMAA 556_ AVTSK 561_ WVADA 566_ FGKEG 571_ IYEAH 576_ IHLNG 581_ YPFLD 586_ VKDEF 591_ THRTL 596_ ATDVM 601_ RPRRG 606_ EPPLS 611_ VLTQD 616_ SMTVE 621_ DVETL 626_ IKETD 631_ YNGFP 636_ VVVSR 641_ DSERL 646_ IGFAQ 651_ RRELI 656_ LAIKN 661_ ARQRQ 666_ EGIVS 671_ NSIMY 676_ FTEEP 681_ PELPA 686_ NSPHP 691_ LKLRR 696_ ILNLS 701_ PFTVT 706_ DHTPM 711_ ETVVD 716_ IFRKL 721_ GLRQC 726_ LVTRS 731_ GRLLG 736_ IITKK 741_ DVLRH 746_ MAQMA 751_NQDPE
1: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (PubMed:18063579, PubMed:23647072, PubMed:25644381, PubMed:27550844, PubMed:28972156). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (PubMed:29845874). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (PubMed:29845874)