H(+)/Cl(-) exchange transporter 5 (Chloride channel protein 5) (ClC-5) (Chloride transporter ClC-5)
1_MAMWQ 6_ GAMDN 11_ RGFQQ 16_ GSFSS 21_ FQNSS 26_ SDEDL 31_ MDIPA 36_ TAMDF 41_ SMRDD 46_ VPPLD 51_ REVGE 56_ DKSYN 61_ GGGIG 66_ SSNRI 71_ MDFLE 76_ EPIPG 81_ VGTYD 86_ DFNTI 91_ DWVRE 96_ KSRDR 101_ DRHRE 106_ ITNKS 111_ KESTW 116_ ALIHS 121_ VSDAF 126_ SGWLL 131_ MLLIG 136_ LLSGS 141_ LAGLI 146_ DISAH 151_ WMTDL 156_ KEGIC 161_ TGGFW 166_ FNHEH 171_ CCWNS 176_ EHVTF 181_ EERDK 186_ CPEWN 191_ SWSQL 196_ IISTD 201_ EGAFA 206_ YIVNY 211_ FMYVL 216_ WALLF 221_ AFLAV 226_ SLVKV 231_ FAPYA 236_ CGSGI 241_ PEIKT 246_ ILSGF 251_ IIRGY 256_ LGKWT 261_ LVIKT 266_ ITLVL 271_ AVSSG 276_ LSLGK 281_ EGPLV 286_ HVACC 291_ CGNIL 296_ CHCFN 301_ KYRKN 306_ EAKRR 311_ EVLSA 316_ AAAAG 321_ VSVAF 326_ GAPIG 331_ GVLFS 336_ LEEVS 341_ YYFPL 346_ KTLWR 351_ SFFAA 356_ LVAAF 361_ TLRSI 366_ NPFGN 371_ SRLVL 376_ FYVEF 381_ HTPWH 386_ LFELV 391_ PFILL 396_ GIFGG 401_ LWGAL 406_ FIRTN 411_ IAWCR 416_ KRKTT 421_ QLGKY 426_ PVIEV 431_ LVVTA 436_ ITAIL 441_ AFPNE 446_ YTRMS 451_ TSELI 456_ SELFN 461_ DCGLL 466_ DSSKL 471_ CDYEN 476_ RFNTS 481_ KGGEL 486_ PDRPA 491_ GVGVY 496_ SAMWQ 501_ LALTL 506_ ILKIV 511_ ITIFT 516_ FGMKI 521_ PSGLF 526_ IPSMA 531_ VGAIA 536_ GRLLG 541_ VGMEQ 546_ LAYYH 551_ QEWTV 556_ FNSWC 561_ SQGAD 566_ CITPG 571_ LYAMV 576_ GAAAC 581_ LGGVT 586_ RMTVS 591_ LVVIM 596_ FELTG 601_ GLEYI 606_ VPLMA 611_ AAMTS 616_ KWVAD 621_ ALGRE 626_ GIYDA 631_ HIRLN 636_ GYPFL 641_ EAKEE 646_ FAHKT 651_ LAMDV 656_ MKPRR 661_ NDPLL 666_ TVLTQ 671_ DSMTV 676_ EDVET 681_ IISET 686_ TYSGF 691_ PVVVS 696_ RESQR 701_ LVGFV 706_ LRRDL 711_ IISIE 716_ NARKK 721_ QDGVV 726_ STSII 731_ YFTEH 736_ SPPLP 741_ PYTPP 746_ TLKLR 751_ NILDL 756_ SPFTV 761_ TDLTP 766_ MEIVV 771_ DIFRK 776_ LGLRQ 781_ CLVTH 786_ NGRLL 791_ GIITK 796_ KDVLK 801_ HIAQM 806_ ANQDP 811_DSILF
1: Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons (PubMed:20466723). Important for normal acidification of the endosome lumen. May play an important role in renal tubular function. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels (Probable)