H(+)/Cl(-) exchange transporter 7 (Chloride channel 7 alpha subunit) (Chloride channel protein 7) (ClC-7)
1_MANVS 6_ KKVSW 11_ SGRDR 16_ DDEEA 21_ APLLR 26_ RTARP 31_ GGGTP 36_ LLNGA 41_ GPGAA 46_ RQSPR 51_ SALFR 56_ VGHMS 61_ SVELD 66_ DELLD 71_ PDMDP 76_ PHPFP 81_ KEIPH 86_ NEKLL 91_ SLKYE 96_ SLDYD 101_ NSENQ 106_ LFLEE 111_ ERRIN 116_ HTAFR 121_ TVEIK 126_ RWVIC 131_ ALIGI 136_ LTGLV 141_ ACFID 146_ IVVEN 151_ LAGLK 156_ YRVIK 161_ GNIDK 166_ FTEKG 171_ GLSFS 176_ LLLWA 181_ TLNAA 186_ FVLVG 191_ SVIVA 196_ FIEPV 201_ AAGSG 206_ IPQIK 211_ CFLNG 216_ VKIPH 221_ VVRLK 226_ TLVIK 231_ VSGVI 236_ LSVVG 241_ GLAVG 246_ KEGPM 251_ IHSGS 256_ VIAAG 261_ ISQGR 266_ STSLK 271_ RDFKI 276_ FEYFR 281_ RDTEK 286_ RDFVS 291_ AGAAA 296_ GVSAA 301_ FGAPV 306_ GGVLF 311_ SLEEG 316_ ASFWN 321_ QFLTW 326_ RIFFA 331_ SMIST 336_ FTLNF 341_ VLSIY 346_ HGNMW 351_ DLSSP 356_ GLINF 361_ GRFDS 366_ EKMAY 371_ TIHEI 376_ PVFIA 381_ MGVVG 386_ GVLGA 391_ VFNAL 396_ NYWLT 401_ MFRIR 406_ YIHRP 411_ CLQVI 416_ EAVLV 421_ AAVTA 426_ TVAFV 431_ LIYSS 436_ RDCQP 441_ LQGGS 446_ MSYPL 451_ QLFCA 456_ DGEYN 461_ SMAAA 466_ FFNTP 471_ EKSVV 476_ SLFHD 481_ PPGSY 486_ NPLTL 491_ GLFTL 496_ VYFFL 501_ ACWTY 506_ GLTVS 511_ AGVFI 516_ PSLLI 521_ GAAWG 526_ RLFGI 531_ SLSYL 536_ TGAAI 541_ WADPG 546_ KYALM 551_ GAAAQ 556_ LGGIV 561_ RMTLS 566_ LTVIM 571_ MEATS 576_ NVTYG 581_ FPIML 586_ VLMTA 591_ KIVGD 596_ VFIEG 601_ LYDMH 606_ IQLQS 611_ VPFLH 616_ WEAPV 621_ TSHSL 626_ TAREV 631_ MSTPV 636_ TCLRR 641_ REKVG 646_ VIVDV 651_ LSDTA 656_ SNHNG 661_ FPVVE 666_ HADDT 671_ QPARL 676_ QGLIL 681_ RSQLI 686_ VLLKH 691_ KVFVE 696_ RSNLG 701_ LVQRR 706_ LRLKD 711_ FRDAY 716_ PRFPP 721_ IQSIH 726_ VSQDE 731_ RECTM 736_ DLSEF 741_ MNPSP 746_ YTVPQ 751_ EASLP 756_ RVFKL 761_ FRALG 766_ LRHLV 771_ VVDNR 776_ NQVVG 781_ LVTRK 786_ DLARY 791_ RLGKR 796_GLEEL
1: Slowly voltage-gated channel mediating the exchange of chloride ions against protons (PubMed:18449189, PubMed:21527911). Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH (PubMed:18449189, PubMed:21527911, PubMed:31155284). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity)