Chloride channel protein ClC-Ka (Chloride channel Ka) (ClC-K1)
1_MEELV 6_ GLREG 11_ FSGDP 16_ VTLQE 21_ LWGPC 26_ PHIRR 31_ AIQGG 36_ LEWLK 41_ QKVFR 46_ LGEDW 51_ YFLMT 56_ LGVLM 61_ ALVSY 66_ AMNFA 71_ IGCVV 76_ RAHQW 81_ LYREI 86_ GDSHL 91_ LRYLS 96_ WTVYP 101_ VALVS 106_ FSSGF 111_ SQSIT 116_ PSSGG 121_ SGIPE 126_ LKTML 131_ AGVIL 136_ EDYLD 141_ IKNFG 146_ AKVVG 151_ LSCTL 156_ ATGST 161_ LFLGK 166_ VGPFV 171_ HLSVM 176_ IAAYL 181_ GRVRT 186_ TTIGE 191_ PENKS 196_ KQNEM 201_ LVAAA 206_ AVGVA 211_ TVFAA 216_ PFSGV 221_ LFSIE 226_ VMSSH 231_ FSVRD 236_ YWRGF 241_ FAATC 246_ GAFIF 251_ RLLAV 256_ FNSEQ 261_ ETITS 266_ LYKTS 271_ FRVDV 276_ PFDLP 281_ EIFFF 286_ VALGG 291_ ICGVL 296_ SCAYL 301_ FCQRT 306_ FLSFI 311_ KTNRY 316_ SSKLL 321_ ATSKP 326_ VYSAL 331_ ATLLL 336_ ASITY 341_ PPGVG 346_ HFLAS 351_ RLSMK 356_ QHLDS 361_ LFDNH 366_ SWALM 371_ TQNSS 376_ PPWPE 381_ ELDPQ 386_ HLWWE 391_ WYHPR 396_ FTIFG 401_ TLAFF 406_ LVMKF 411_ WMLIL 416_ ATTIP 421_ MPAGY 426_ FMPIF 431_ ILGAA 436_ IGRLL 441_ GEALA 446_ VAFPE 451_ GIVTG 456_ GVTNP 461_ IMPGG 466_ YALAG 471_ AAAFS 476_ GAVTH 481_ TISTA 486_ LLAFE 491_ LTGQI 496_ VHALP 501_ VLMAV 506_ LAANA 511_ IAQSC 516_ QPSFY 521_ DGTII 526_ VKKLP 531_ YLPRI 536_ LGRNI 541_ GSHHV 546_ RVEHF 551_ MNHSI 556_ TTLAK 561_ DTPLE 566_ EVVKV 571_ VTSTD 576_ VTEYP 581_ LVEST 586_ ESQIL 591_ VGIVQ 596_ RAQLV 601_ QALQA 606_ EPPSR 611_ APGHQ 616_ QCLQD 621_ ILARG 626_ CPTEP 631_ VTLTL 636_ FSETT 641_ LHQAQ 646_ NLFKL 651_ LNLQS 656_ LFVTS 661_ RGRAV 666_ GCVSW 671_ VEMKK 676_ AISNL 681_TNPPA
1: Anion-selective channel permeable to small monovalent anions with ion selectivity for chloride > bromide > nitrate > iodide (PubMed:11734858, PubMed:12111250). Forms a homodimeric channel where each subunit has its own ion conduction pathway. May conduct double-barreled currents controlled by two types of gates, two fast gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously (PubMed:11734858, PubMed:12111250, PubMed:18310267, PubMed:18776122, PubMed:19646679, PubMed:20538786). Assembles with the regulatory subunit BSND/Barttin for sorting at the basolateral plasma membrane domain and functional switch to the ion conducting state. CLCNKA:BSND channels display mostly a linear current-voltage relationship with fast gating at negative potentials (PubMed:11734858, PubMed:12111250, PubMed:18310267, PubMed:18776122, PubMed:20538786). Mediates transepithelial chloride transport from the lumen to interstitial compartment along the thin ascending limb of Henle's loop, contributing to generation of hypertonic medullary interstitium as a countercurrent system to achieve urine concentration (By similarity) (PubMed:15044642). Conducts chloride currents in the stria vascularis of the inner ear to establish the endocochlear potential necessary for normal hearing (PubMed:15044642, PubMed:18310267, PubMed:19646679)