Chloride channel protein ClC-Kb (Chloride channel Kb) (ClC-K2)
1_MEEFV 6_ GLREG 11_ SSGNP 16_ VTLQE 21_ LWGPC 26_ PRIRR 31_ GIRGG 36_ LEWLK 41_ QKLFR 46_ LGEDW 51_ YFLMT 56_ LGVLM 61_ ALVSC 66_ AMDLA 71_ VESVV 76_ RAHQW 81_ LYREI 86_ GDSHL 91_ LRYLS 96_ WTVYP 101_ VALVS 106_ FSSGF 111_ SQSIT 116_ PSSGG 121_ SGIPE 126_ VKTML 131_ AGVVL 136_ EDYLD 141_ IKNFG 146_ AKVVG 151_ LSCTL 156_ ACGST 161_ LFLGK 166_ VGPFV 171_ HLSVM 176_ MAAYL 181_ GRVRT 186_ TTIGE 191_ PENKS 196_ KQNEM 201_ LVAAA 206_ AVGVA 211_ TVFAA 216_ PFSGV 221_ LFSIE 226_ VMSSH 231_ FSVWD 236_ YWRGF 241_ FAATC 246_ GAFMF 251_ RLLAV 256_ FNSEQ 261_ ETITS 266_ LYKTS 271_ FRVDV 276_ PFDLP 281_ EIFFF 286_ VALGG 291_ LCGIL 296_ GSAYL 301_ FCQRI 306_ FFGFI 311_ RNNRF 316_ SSKLL 321_ ATSKP 326_ VYSAL 331_ ATLVL 336_ ASITY 341_ PPSAG 346_ RFLAS 351_ RLSMK 356_ QHLDS 361_ LFDNH 366_ SWALM 371_ TQNSS 376_ PPWPE 381_ ELDPQ 386_ HLWWE 391_ WYHPR 396_ FTIFG 401_ TLAFF 406_ LVMKF 411_ WMLIL 416_ ATTIP 421_ MPAGY 426_ FMPIF 431_ VYGAA 436_ IGRLF 441_ GETLS 446_ FIFPE 451_ GIVAG 456_ GITNP 461_ IMPGG 466_ YALAG 471_ AAAFS 476_ GAVTH 481_ TISTA 486_ LLAFE 491_ VTGQI 496_ VHALP 501_ VLMAV 506_ LAANA 511_ IAQSC 516_ QPSFY 521_ DGTVI 526_ VKKLP 531_ YLPRI 536_ LGRNI 541_ GSHRV 546_ RVEHF 551_ MNHSI 556_ TTLAK 561_ DMPLE 566_ EVVKV 571_ VTSTD 576_ VAKYP 581_ LVEST 586_ ESQIL 591_ VGIVR 596_ RAQLV 601_ QALKA 606_ EPPSW 611_ APGHQ 616_ QCLQD 621_ ILAAG 626_ CPTEP 631_ VTLKL 636_ SPETS 641_ LHEAH 646_ NLFEL 651_ LNLHS 656_ LFVTS 661_ RGRAV 666_ GCVSW 671_ VEMKK 676_ AISNL 681_TNPPA
1: Anion-selective channel permeable to small monovalent anions with ion selectivity for chloride > bromide > nitrate > iodide (PubMed:11734858, PubMed:12111250). Forms a homodimeric channel where each subunit has its own ion conduction pathway. May conduct double-barreled currents controlled by two types of gates, two fast gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously (PubMed:11734858, PubMed:12111250, PubMed:16849430, PubMed:18776122, PubMed:19646679). Assembles with the regulatory subunit BSND/Barttin for sorting at the basolateral plasma membrane domain and functional switch to the ion conducting state. CLCNKB:BSND channels display mostly a linear current-voltage relationship controlled by common gate (PubMed:11734858, PubMed:12111250, PubMed:16849430, PubMed:18776122, PubMed:19646679). Mediates chloride conductance along nephron segments, namely the thick ascending limb of Henle's loop, convoluted tubule and the collecting duct, contributing to the maintenance of systemic acid-base and electrolyte homeostasis (By similarity). Conducts chloride currents in the stria vascularis of the inner ear to establish the endocochlear potential necessary for normal hearing (PubMed:15044642, PubMed:18310267, PubMed:19646679)