Vesicle-associated membrane protein 7 (VAMP-7) (Synaptobrevin-like protein 1) (Tetanus-insensitive VAMP) (Ti-VAMP)
1_MAILF 6_ AVVAR 11_ GTTIL 16_ AKHAW 21_ CGGNF 26_ LEVTE 31_ QILAK 36_ IPSEN 41_ NKLTY 46_ SHGNY 51_ LFHYI 56_ CQDRI 61_ VYLCI 66_ TDDDF 71_ ERSRA 76_ FNFLN 81_ EIKKR 86_ FQTTY 91_ GSRAQ 96_ TALPY 101_ AMNSE 106_ FSSVL 111_ AAQLK 116_ HHSEN 121_ KGLDK 126_ VMETQ 131_ AQVDE 136_ LKGIM 141_ VRNID 146_ LVAQR 151_ GERLE 156_ LLIDK 161_ TENLV 166_ DSSVT 171_ FKTTS 176_ RNLAR 181_ AMCMK 186_ NLKLT 191_ IIIII 196_ VSIVF 201_ IYIIV 206_ SPLCG 211_GFTWP
1: Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation