G-protein coupled receptor 143 (Ocular albinism type 1 protein)
1_MASPR 6_ LGTFC 11_ CPTRD 16_ AATQL 21_ VLSFQ 26_ PRAFH 31_ ALCLG 36_ SGGLR 41_ LALGL 46_ LQLLP 51_ GRRPA 56_ GPGSP 61_ ATSPP 66_ ASVRI 71_ LRAAA 76_ ACDLL 81_ GCLGM 86_ VIRST 91_ VWLGF 96_ PNFVD 101_ SVSDM 106_ NHTEI 111_ WPAAF 116_ CVGSA 121_ MWIQL 126_ LYSAC 131_ FWWLF 136_ CYAVD 141_ AYLVI 146_ RRSAG 151_ LSTIL 156_ LYHIM 161_ AWGLA 166_ TLLCV 171_ EGAAM 176_ LYYPS 181_ VSRCE 186_ RGLDH 191_ AIPHY 196_ VTMYL 201_ PLLLV 206_ LVANP 211_ ILFQK 216_ TVTAV 221_ ASLLK 226_ GRQGI 231_ YTENE 236_ RRMGA 241_ VIKIR 246_ FFKIM 251_ LVLII 256_ CWLSN 261_ IINES 266_ LLFYL 271_ EMQTD 276_ INGGS 281_ LKPVR 286_ TAAKT 291_ TWFIM 296_ GILNP 301_ AQGFL 306_ LSLAF 311_ YGWTG 316_ CSLGF 321_ QSPRK 326_ EIQWE 331_ SLTTS 336_ AAEGA 341_ HPSPL 346_ MPHEN 351_ PASGK 356_ VSQVG 361_ GQTSD 366_ EALSM 371_ LSEGS 376_ DASTI 381_ EIHTA 386_ SESCN 391_ KNEGD 396_PALPT
1: Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Also plays a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport