Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2)
1_MPLAQ 6_ LADPW 11_ QKMAV 16_ ESPSD 21_ SAENG 26_ QQIMD 31_ EPMGE 36_ EEINP 41_ QTEEV 46_ SIKEI 51_ AITHH 56_ VKEGH 61_ EKADP 66_ SQFEL 71_ LKVLG 76_ QGSFG 81_ KVFLV 86_ KKISG 91_ SDARQ 96_ LYAMK 101_ VLKKA 106_ TLKVR 111_ DRVRT 116_ KMERD 121_ ILVEV 126_ NHPFI 131_ VKLHY 136_ AFQTE 141_ GKLYL 146_ ILDFL 151_ RGGDL 156_ FTRLS 161_ KEVMF 166_ TEEDV 171_ KFYLA 176_ ELALA 181_ LDHLH 186_ SLGII 191_ YRDLK 196_ PENIL 201_ LDEEG 206_ HIKLT 211_ DFGLS 216_ KESID 221_ HEKKA 226_ YSFCG 231_ TVEYM 236_ APEVV 241_ NRRGH 246_ TQSAD 251_ WWSFG 256_ VLMFE 261_ MLTGT 266_ LPFQG 271_ KDRKE 276_ TMTMI 281_ LKAKL 286_ GMPQF 291_ LSPEA 296_ QSLLR 301_ MLFKR 306_ NPANR 311_ LGAGP 316_ DGVEE 321_ IKRHS 326_ FFSTI 331_ DWNKL 336_ YRREI 341_ HPPFK 346_ PATGR 351_ PEDTF 356_ YFDPE 361_ FTAKT 366_ PKDSP 371_ GIPPS 376_ ANAHQ 381_ LFRGF 386_ SFVAI 391_ TSDDE 396_ SQAMQ 401_ TVGVH 406_ SIVQQ 411_ LHRNS 416_ IQFTD 421_ GYEVK 426_ EDIGV 431_ GSYSV 436_ CKRCI 441_ HKATN 446_ MEFAV 451_ KIIDK 456_ SKRDP 461_ TEEIE 466_ ILLRY 471_ GQHPN 476_ IITLK 481_ DVYDD 486_ GKYVY 491_ VVTEL 496_ MKGGE 501_ LLDKI 506_ LRQKF 511_ FSERE 516_ ASAVL 521_ FTITK 526_ TVEYL 531_ HAQGV 536_ VHRDL 541_ KPSNI 546_ LYVDE 551_ SGNPE 556_ SIRIC 561_ DFGFA 566_ KQLRA 571_ ENGLL 576_ MTPCY 581_ TANFV 586_ APEVL 591_ KRQGY 596_ DAACD 601_ IWSLG 606_ VLLYT 611_ MLTGY 616_ TPFAN 621_ GPDDT 626_ PEEIL 631_ ARIGS 636_ GKFSL 641_ SGGYW 646_ NSVSD 651_ TAKDL 656_ VSKML 661_ HVDPH 666_ QRLTA 671_ ALVLR 676_ HPWIV 681_ HWDQL 686_ PQYQL 691_ NRQDA 696_ PHLVK 701_ GAMAA 706_ TYSAL 711_ NRNQS 716_ PVLEP 721_ VGRST 726_ LAQRR 731_GIKKI
1: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:16213824, PubMed:16223362, PubMed:17360704, PubMed:9770464). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:10436156, PubMed:9770464). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:8250835). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:18508509, PubMed:18813292). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:18722121). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (By similarity). In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3 (By similarity). Negatively regulates EGF-induced MAPK1/3 phosphorylation via phosphorylation of SOS1 (By similarity). Phosphorylates SOS1 at 'Ser-1134' and 'Ser-1161' that create YWHAB and YWHAE binding sites and which contribute to the negative regulation of MAPK1/3 phosphorylation (By similarity). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). Acts as a regulator of osteoblast differentiation by mediating phosphorylation of ATF4, thereby promoting ATF4 transactivation activity (By similarity)