Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38)
1_MDTKS 6_ ILEEL 11_ LLKRS 16_ QQKKK 21_ MSPNN 26_ YKERL 31_ FVLTK 36_ TNLSY 41_ YEYDK 46_ MKRGS 51_ RKGSI 56_ EIKKI 61_ RCVEK 66_ VNLEE 71_ QTPVE 76_ RQYPF 81_ QIVYK 86_ DGLLY 91_ VYASN 96_ EESRS 101_ QWLKA 106_ LQKEI 111_ RGNPH 116_ LLVKY 121_ HSGFF 126_ VDGKF 131_ LCCQQ 136_ SCKAA 141_ PGCTL 146_ WEAYA 151_ NLHTA 156_ VNEEK 161_ HRVPT 166_ FPDRV 171_ LKIPR 176_ AVPVL 181_ KMDAP 186_ SSSTT 191_ LAQYD 196_ NESKK 201_ NYGSQ 206_ PPSSS 211_ TSLAQ 216_ YDSNS 221_ KKIYG 226_ SQPNF 231_ NMQYI 236_ PREDF 241_ PDWWQ 246_ VRKLK 251_ SSSSS 256_ EDVAS 261_ SNQKE 266_ RNVNH 271_ TTSKI 276_ SWEFP 281_ ESSSS 286_ EEEEN 291_ LDDYD 296_ WFAGN 301_ ISRSQ 306_ SEQLL 311_ RQKGK 316_ EGAFM 321_ VRNSS 326_ QVGMY 331_ TVSLF 336_ SKAVN 341_ DKKGT 346_ VKHYH 351_ VHTNA 356_ ENKLY 361_ LAENY 366_ CFDSI 371_ PKLIH 376_ YHQHN 381_ SAGMI 386_ TRLRH 391_ PVSTK 396_ ANKVP 401_ DSVSL 406_ GNGIW 411_ ELKRE 416_ EITLL 421_ KELGS 426_ GQFGV 431_ VQLGK 436_ WKGQY 441_ DVAVK 446_ MIKEG 451_ SMSED 456_ EFFQE 461_ AQTMM 466_ KLSHP 471_ KLVKF 476_ YGVCS 481_ KEYPI 486_ YIVTE 491_ YISNG 496_ CLLNY 501_ LRSHG 506_ KGLEP 511_ SQLLE 516_ MCYDV 521_ CEGMA 526_ FLESH 531_ QFIHR 536_ DLAAR 541_ NCLVD 546_ RDLCV 551_ KVSDF 556_ GMTRY 561_ VLDDQ 566_ YVSSV 571_ GTKFP 576_ VKWSA 581_ PEVFH 586_ YFKYS 591_ SKSDV 596_ WAFGI 601_ LMWEV 606_ FSLGK 611_ QPYDL 616_ YDNSQ 621_ VVLKV 626_ SQGHR 631_ LYRPH 636_ LASDT 641_ IYQIM 646_ YSCWH 651_ ELPEK 656_ RPTFQ 661_ QLLSS 666_IEPLR
1: Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Also plays a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells