cAMP-dependent protein kinase catalytic subunit PRKX (PrKX) (Protein kinase X) (Protein kinase X-linked) (Serine/threonine-protein kinase PRKX) (EC 2.7.11.1) (Protein kinase PKX1)
1_MEAPG 6_ LAQAA 11_ AAESD 16_ SRKVA 21_ EETPD 26_ GAPAL 31_ CPSPE 36_ ALSPE 41_ PPVYS 46_ LQDFD 51_ TLATV 56_ GTGTF 61_ GRVHL 66_ VKEKT 71_ AKHFF 76_ ALKVM 81_ SIPDV 86_ IRLKQ 91_ EQHVH 96_ NEKSV 101_ LKEVS 106_ HPFLI 111_ RLFWT 116_ WHDER 121_ FLYML 126_ MEYVP 131_ GGELF 136_ SYLRN 141_ RGRFS 146_ STTGL 151_ FYSAE 156_ IICAI 161_ EYLHS 166_ KEIVY 171_ RDLKP 176_ ENILL 181_ DRDGH 186_ IKLTD 191_ FGFAK 196_ KLVDR 201_ TWTLC 206_ GTPEY 211_ LAPEV 216_ IQSKG 221_ HGRAV 226_ DWWAL 231_ GILIF 236_ EMLSG 241_ FPPFF 246_ DDNPF 251_ GIYQK 256_ ILAGK 261_ IDFPR 266_ HLDFH 271_ VKDLI 276_ KKLLV 281_ VDRTR 286_ RLGNM 291_ KNGAN 296_ DVKHH 301_ RWFRS 306_ VDWEA 311_ VPQRK 316_ LKPPI 321_ VPKIA 326_ GDGDT 331_ SNFET 336_ YPEND 341_ WDTAA 346_ PVPQK 351_DLEIF
1: Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation