Adenylate cyclase type 7 (EC 4.6.1.1) (ATP pyrophosphate-lyase 7) (Adenylate cyclase type VII) (Adenylyl cyclase 7)
1_MPAKG 6_ RYFLN 11_ EGEEG 16_ PDQDA 21_ LYEKY 26_ QLTSQ 31_ HGPLL 36_ LTLLL 41_ VAATA 46_ CVALI 51_ IIAFS 56_ QGDPS 61_ RHQAI 66_ LGMAF 71_ LVLAV 76_ FAALS 81_ VLMYV 86_ ECLLR 91_ RWLRA 96_ LALLT 101_ WACLV 106_ ALGYV 111_ LVFDA 116_ WTKAA 121_ CAWEQ 126_ VPFFL 131_ FIVFV 136_ VYTLL 141_ PFSMR 146_ GAVAV 151_ GAVST 156_ ASHLL 161_ VLGSL 166_ MGGFT 171_ TPSVR 176_ VGLQL 181_ LANAV 186_ IFLCG 191_ NLTGA 196_ FHKHQ 201_ MQDAS 206_ RDLFT 211_ YTVKC 216_ IQIRR 221_ KLRIE 226_ KRQQE 231_ NLLLS 236_ VLPAH 241_ ISMGM 246_ KLAII 251_ ERLKE 256_ HGDRR 261_ CMPDN 266_ NFHSL 271_ YVKRH 276_ QNVSI 281_ LYADI 286_ VGFTQ 291_ LASDC 296_ SPKEL 301_ VVVLN 306_ ELFGK 311_ FDQIA 316_ KANEC 321_ MRIKI 326_ LGDCY 331_ YCVSG 336_ LPVSL 341_ PTHAR 346_ NCVKM 351_ GLDMC 356_ QAIKQ 361_ VREAT 366_ GVDIN 371_ MRVGI 376_ HSGNV 381_ LCGVI 386_ GLRKW 391_ QYDVW 396_ SHDVS 401_ LANRM 406_ EAAGV 411_ PGRVH 416_ ITEAT 421_ LKHLD 426_ KAYEV 431_ EDGHG 436_ QQRDP 441_ YLKEM 446_ NIRTY 451_ LVIDP 456_ RSQQP 461_ PPPSQ 466_ HLPRP 471_ KGDAA 476_ LKMRA 481_ SVRMT 486_ RYLES 491_ WGAAR 496_ PFAHL 501_ NHRES 506_ VSSGE 511_ THVPN 516_ GRRPK 521_ SVPQR 526_ HRRTP 531_ DRSMS 536_ PKGRS 541_ EDDSY 546_ DDEML 551_ SAIEG 556_ LSSTR 561_ PCCSK 566_ SDDFY 571_ TFGSI 576_ FLEKG 581_ FEREY 586_ RLAPI 591_ PRARH 596_ DFACA 601_ SLIFV 606_ CILLV 611_ HVLLM 616_ PRTAA 621_ LGVSF 626_ GLVAC 631_ VLGLV 636_ LGLCF 641_ ATKFS 646_ RCCPA 651_ RGTLC 656_ TISER 661_ VETQP 666_ LLRLT 671_ LAVLT 676_ IGSLL 681_ TVAII 686_ NLPLM 691_ PFQVP 696_ ELPVG 701_ NETGL 706_ LAASS 711_ KTRAL 716_ CEPLP 721_ YYTCS 726_ CVLGF 731_ IACSV 736_ FLRMS 741_ LEPKV 746_ VLLTV 751_ ALVAY 756_ LVLFN 761_ LSPCW 766_ QWDCC 771_ GQGLG 776_ NLTKP 781_ NGTTS 786_ GTPSC 791_ SWKDL 796_ KTMTN 801_ FYLVL 806_ FYITL 811_ LTLSR 816_ QIDYY 821_ CRLDC 826_ LWKKK 831_ FKKEH 836_ EEFET 841_ MENVN 846_ RLLLE 851_ NVLPA 856_ HVAAH 861_ FIGDK 866_ LNEDW 871_ YHQSY 876_ DCVCV 881_ MFASV 886_ PDFKV 891_ FYTEC 896_ DVNKE 901_ GLECL 906_ RLLNE 911_ IIADF 916_ DELLL 921_ KPKFS 926_ GVEKI 931_ KTIGS 936_ TYMAA 941_ AGLSV 946_ ASGHE 951_ NQELE 956_ RQHAH 961_ IGVMV 966_ EFSIA 971_ LMSKL 976_ DGINR 981_ HSFNS 986_ FRLRV 991_ GINHG 996_ PVIAG 1001_ VIGAR 1006_ KPQYD 1011_ IWGNT 1016_ VNVAS 1021_ RMEST 1026_ GELGK 1031_ IQVTE 1036_ ETCTI 1041_ LQGLG 1046_ YSCEC 1051_ RGLIN 1056_ VKGKG 1061_ ELRTY 1066_ FVCTD 1071_TAKFQ
1: Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors (Probable). Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13 (PubMed:18541530, PubMed:23229509). Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13) (By similarity). Functions in signaling cascades activated namely by dopamine and C5 alpha chain and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G protein with G beta:gamma complex (PubMed:23229509, PubMed:23842570). Functions, through cAMP response regulation, to keep inflammation under control during bacterial infection by sensing the presence of serum factors, such as the bioactive lysophospholipid (LPA) that regulate LPS-induced TNF-alpha production. However, it is also required for the optimal functions of B and T cells during adaptive immune responses by regulating cAMP synthesis in both B and T cells (By similarity)