Caspase-5 (CASP-5) (EC 3.4.22.58) (ICE(rel)-III) (Protease ICH-3) (Protease TY) [Cleaved into: Caspase-5 subunit p20; Caspase-5 subunit p10]
1_MAEDS 6_ GKKKR 11_ RKNFE 16_ AMFKG 21_ ILQSG 26_ LDNFV 31_ INHML 36_ KNNVA 41_ GQTSI 46_ QTLVP 51_ NTDQK 56_ STSVK 61_ KDNHK 66_ KKTVK 71_ MLEYL 76_ GKDVL 81_ HGVFN 86_ YLAKH 91_ DVLTL 96_ KEEEK 101_ KKYYD 106_ TKIED 111_ KALIL 116_ VDSLR 121_ KNRVA 126_ HQMFT 131_ QTLLN 136_ MDQKI 141_ TSVKP 146_ LLQIE 151_ AGPPE 156_ SAEST 161_ NILKL 166_ CPREE 171_ FLRLC 176_ KKNHD 181_ EIYPI 186_ KKRED 191_ RRRLA 196_ LIICN 201_ TKFDH 206_ LPARN 211_ GAHYD 216_ IVGMK 221_ RLLQG 226_ LGYTV 231_ VDEKN 236_ LTARD 241_ MESVL 246_ RAFAA 251_ RPEHK 256_ SSDST 261_ FLVLM 266_ SHGIL 271_ EGICG 276_ TAHKK 281_ KKPDV 286_ LLYDT 291_ IFQIF 296_ NNRNC 301_ LSLKD 306_ KPKVI 311_ IVQAC 316_ RGEKH 321_ GELWV 326_ RDSPA 331_ SLALI 336_ SSQSS 341_ ENLEA 346_ DSVCK 351_ IHEEK 356_ DFIAF 361_ CSSTP 366_ HNVSW 371_ RDRTR 376_ GSIFI 381_ TELIT 386_ CFQKY 391_ SCCCH 396_ LMEIF 401_ RKVQK 406_ SFEVP 411_ QAKAQ 416_ MPTIE 421_ RATLT 426_RDFYL
1: Thiol protease that acts as a mediator of programmed cell death (PubMed:28314590, PubMed:29898893). Initiates pyroptosis, a programmed lytic cell death pathway through cleavage of Gasdermin-D (GSDMD): cleavage releases the N-terminal gasdermin moiety (Gasdermin-D, N-terminal) that binds to membranes and forms pores, triggering pyroptosis (PubMed:29898893). Also mediates cleavage and maturation of IL18 (PubMed:37993714). Cleavage of GSDMD and IL18 is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP4 (PubMed:37993714). During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation (PubMed:28314590)