Cyclin-H (MO15-associated protein) (p34) (p37)
1_MYHNS 6_ SQKRH 11_ WTFSS 16_ EEQLA 21_ RLRAD 26_ ANRKF 31_ RCKAV 36_ ANGKV 41_ LPNDP 46_ VFLEP 51_ HEEMT 56_ LCKYY 61_ EKRLL 66_ EFCSV 71_ FKPAM 76_ PRSVV 81_ GTACM 86_ YFKRF 91_ YLNNS 96_ VMEYH 101_ PRIIM 106_ LTCAF 111_ LACKV 116_ DEFNV 121_ SSPQF 126_ VGNLR 131_ ESPLG 136_ QEKAL 141_ EQILE 146_ YELLL 151_ IQQLN 156_ FHLIV 161_ HNPYR 166_ PFEGF 171_ LIDLK 176_ TRYPI 181_ LENPE 186_ ILRKT 191_ ADDFL 196_ NRIAL 201_ TDAYL 206_ LYTPS 211_ QIALT 216_ AILSS 221_ ASRAG 226_ ITMES 231_ YLSES 236_ LMLKE 241_ NRTCL 246_ SQLLD 251_ IMKSM 256_ RNLVK 261_ KYEPP 266_ RSEEV 271_ AVLKQ 276_ KLERC 281_ HSAEL 286_ ALNVI 291_ TKKRK 296_ GYEDD 301_ DYVSK 306_ KSKHE 311_ EEEWT 316_DDDLV
1: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle