CDK-activating kinase assembly factor MAT1 (CDK7/cyclin-H assembly factor) (Cyclin-G1-interacting protein) (Menage a trois) (RING finger protein 66) (RING finger protein MAT1) (p35) (p36)
1_MDDQG 6_ CPRCK 11_ TTKYR 16_ NPSLK 21_ LMVNV 26_ CGHTL 31_ CESCV 36_ DLLFV 41_ RGAGN 46_ CPECG 51_ TPLRK 56_ SNFRV 61_ QLFED 66_ PTVDK 71_ EVEIR 76_ KKVLK 81_ IYNKR 86_ EEDFP 91_ SLREY 96_ NDFLE 101_ EVEEI 106_ VFNLT 111_ NNVDL 116_ DNTKK 121_ KMEIY 126_ QKENK 131_ DVIQK 136_ NKLKL 141_ TREQE 146_ ELEEA 151_ LEVER 156_ QENEQ 161_ RRLFI 166_ QKEEQ 171_ LQQIL 176_ KRKNK 181_ QAFLD 186_ ELESS 191_ DLPVA 196_ LLLAQ 201_ HKDRS 206_ TQLEM 211_ QLEKP 216_ KPVKP 221_ VTFST 226_ GIKMG 231_ QHISL 236_ APIHK 241_ LEEAL 246_ YEYQP 251_ LQIET 256_ YGPHV 261_ PELEM 266_ LGRLG 271_ YLNHV 276_ RAASP 281_ QDLAG 286_ GYTSS 291_ LACHR 296_ ALQDA 301_FSGLF
1: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II