Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (HSPK 36) (Never in mitosis A-related kinase 3) (NimA-related protein kinase 3)
1_MDDYM 6_ VLRMI 11_ GEGSF 16_ GRALL 21_ VQHES 26_ SNQMF 31_ AMKEI 36_ RLPKS 41_ FSNTQ 46_ NSRKE 51_ AVLLA 56_ KMKHP 61_ NIVAF 66_ KESFE 71_ AEGHL 76_ YIVME 81_ YCDGG 86_ DLMQK 91_ IKQQK 96_ GKLFP 101_ EDMIL 106_ NWFTQ 111_ MCLGV 116_ NHIHK 121_ KRVLH 126_ RDIKS 131_ KNIFL 136_ TQNGK 141_ VKLGD 146_ FGSAR 151_ LLSNP 156_ MAFAC 161_ TYVGT 166_ PYYVP 171_ PEIWE 176_ NLPYN 181_ NKSDI 186_ WSLGC 191_ ILYEL 196_ CTLKH 201_ PFQAN 206_ SWKNL 211_ ILKVC 216_ QGCIS 221_ PLPSH 226_ YSYEL 231_ QFLVK 236_ QMFKR 241_ NPSHR 246_ PSATT 251_ LLSRG 256_ IVARL 261_ VQKCL 266_ PPEII 271_ MEYGE 276_ EVLEE 281_ IKNSK 286_ HNTPR 291_ KKTNP 296_ SRIRI 301_ ALGNE 306_ ASTVQ 311_ EEEQD 316_ RKGSH 321_ TDLES 326_ INENL 331_ VESAL 336_ RRVNR 341_ EEKGN 346_ KSVHL 351_ RKASS 356_ PNLHR 361_ RQWEK 366_ NVPNT 371_ ALTAL 376_ ENASI 381_ LTSSL 386_ TAEDD 391_ RGGSV 396_ IKYSK 401_ NTTRK 406_ QWLKE 411_ TPDTL 416_ LNILK 421_ NADLS 426_ LAFQT 431_ YTIYR 436_ PGSEG 441_ FLKGP 446_ LSEET 451_ EASDS 456_ VDGGH 461_ DSVIL 466_ DPERL 471_ EPGLD 476_ EEDTD 481_ FEEED 486_ DNPDW 491_ VSELK 496_ KRAGW 501_QGLCD
1: Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2